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ChemicalBook CAS DataBase List N-Ethoxycarbonylmethyl-oxalamic acid ethyl ester
29655-79-6

N-Ethoxycarbonylmethyl-oxalamic acid ethyl ester synthesis

5synthesis methods
Glycine ethyl ester hydrochloride

623-33-6

Ethyl chlorooxoacetate

4755-77-5

N-Ethoxycarbonylmethyl-oxalamic acid ethyl ester

29655-79-6

Example 2 II: Compound 4 was prepared using ethyl glycinate hydrochloride and ethyl oxalyl chloride monoethyl ester as starting materials with reference to the literature (J. Heterocycl. Chem. 1995, 32, 1693-1702).Subsequently, the reduction reaction was carried out using the NaBH4/LiCl system in ethanol solution. Further oxidation by Dess-Martin oxidizer gave the target aldehyde 6 in 25% overall yield (two-step reaction).

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Yield:29655-79-6 92.8%

Reaction Conditions:

with triethylamine in 1,2-dichloro-ethane at 20; for 16 h;Substitution;

References:

Fleitz, Fred J.;Lyle, Terry A.;Zheng, Nan;Armstrong III, Joseph D.;Volante [Synthetic Communications,2000,vol. 30,# 17,p. 3171 - 3180]