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ChemicalBook CAS DataBase List N-ethylpyridin-3-amine
32405-70-2

N-ethylpyridin-3-amine synthesis

8synthesis methods
3-Aminopyridine

462-08-8

Acetonitrile

75-05-8

N-ethylpyridin-3-amine

32405-70-2

GENERAL STEPS: 3-Aminopyridine (2.0 g, 21.2 mmol), acetonitrile (4.36 g, 106 mmol) and 10% Pd/C catalyst (0.2 g) were dissolved in methanol (20 mL). The reaction mixture was stirred at 25°C under hydrogen atmosphere for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 5-10% methanol/dichloromethane as eluent to afford N-ethylpyridin-3-amine (0.7 g).

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Yield:32405-70-2 92 % Chromat. ,52896-81-8 1 % Chromat.

Reaction Conditions:

with (η6-1,3,5-cyclooctatriene)(η4-1,5-cyclooctadiene)ruthenium(0) at 180; for 5 h;Product distribution;other reagents;

References:

Watanabe, Yoshihisa;Morisaki, Yasuhiro;Kondo, Teruyuki;Mitsudo, Take-Aki [Journal of Organic Chemistry,1996,vol. 61,# 13,p. 4214 - 4218]

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