N-METHYLSUCCINIMIDE synthesis
- Product Name:N-METHYLSUCCINIMIDE
- CAS Number:1121-07-9
- Molecular formula:C5H7NO2
- Molecular Weight:113.11
108-30-5
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593-51-1
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$21.00/100g
1121-07-9
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$9.00/1g
Yield:1121-07-9 90%
Reaction Conditions:
at 110; for 0.0166667 h;Microwave irradiation;Green chemistry;Temperature;Time;
Steps:
4
Succinic anhydride (4.0 mmol) and methylamine hydrochloride (4.5 mmol) were charged into a 25 ml round bottomed flask and placed in a milestone microwave reactor fitted with a condenser.
The mixture was irradiated at 110° C. by an energy input of 900 W for 1 minute.
The reaction mixture was being cooled to room temperature and extracted with ethyl acetate.
The combined organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure.
The crude product was purified by crystallization with n-hexane to yield pure N-methyl succinimide (NMS) in 90% yield.
References:
KHATRI, Praveen Kumar;JAIN, Suman Lata;CHATERJEE, Alok Kumar;BIR, Sain US2015/65731, 2015, A1 Location in patent:Paragraph 0047
872-50-4
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1121-07-9
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930-88-1
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1121-07-9
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67-56-1
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638-32-4
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123-56-8
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1121-07-9
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110-15-6
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56269-39-7
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