N-METHYLTAURINE SODIUM SALT synthesis

Yield:4316-74-9 482.3 g

Reaction Conditions:

Stage #1:formaldehyd;sodium taurinate with tetrakis(triphenylphosphine) palladium⁽⁰⁾;scandium(III) chloride;cerium(III) chloride;(R,S)-(±)-1-(2-diphenylphosphino-1-naphthyl)isoquinoline in water at 80; for 6 h;Molecular sieve;
Stage #2: with hydrogen in water under 5250.53 Torr; for 7 h;Temperature;Reagent/catalyst;

Steps:

1-5 Preparation of sodium methyl taurine:
Mix 455g of sodium taurine, 250.9g of 37% formaldehyde aqueous solution with 22.75g of the prepared catalyst and add it to the hydrogenation kettle. The temperature is raised to 80 ° C and stirred for 6h. Hydrogen is introduced to the pressure of 7 barg for 7h;The obtained mixed solution was filtered to remove the solid catalyst, the reaction liquid was separated and poured into a crystallization kettle, the crystallization temperature was set at 80 ° C. and the crystallization was performed for 4 h. The obtained mixed liquid was subjected to suction filtration, and the resulting filter cake was dried at 100 ° C. 9h. Thus, about 482.3 g of sodium methyl taurine was obtained. The conversion rate is 97.8%, and the selectivity is 98.96%.

References:

Wanhua Chemical Group Co., Ltd.;Li Jianfeng;Liu Jie;Gui Zhenyou;Ren Juan;Chen Laizhong;Zhang Yongzhen CN110963946, 2020, A Location in patent:Paragraph 0036-0070

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