ChemicalBook CAS DataBase List N-METHYLSACCHARIN

N-METHYLSACCHARIN synthesis

14synthesis methods

Product Name:N-METHYLSACCHARIN
CAS Number:15448-99-4
Molecular formula:C8H7NO3S
Molecular Weight:197.21

67-56-1 Synthesis

67-56-1
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$7.29/5ml-f

81-07-2
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$13.98/25G

15448-99-4
89 suppliers
$26.00/250mg

Yield: 92%

Reaction Conditions:

with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 0 - 20;regioselective reaction;Mitsunobu Displacement;

Steps:

Alkylation of saccharin under Mitsunobu conditions, general procedure
General procedure: Diisopropyl azodicarboxylate (DIAD, 4.5 mmol) was placed in a 50 mL round-bottomed flask equipped with a stirring bar. Then triphenylphosphine (Ph3P, 4.5 mmol) and dry tetrahydrofuran (THF, 20 mL) were added and the solution was cooled in an ice bath. Then the alcohol(3.0 mmol) was added. The mixture was then stirred for 10 minand a solution of saccharin (3.0 mmol) in dry THF (5 mL) was added dropwise. After being stirred for 30 min, the flask was removed from the ice bath and the solution was stirred at room temperature, and monitored by TLC. When the reaction was judged to be complete, the organic solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/EtOAc (v/v = 10:1) as the eluent to give the products. All the isolated products were characterised by physical and spectroscopic data and also by comparison with authentic samples. ^5,7-10The physicaland spectral data of the products are shown as follows. 2-Methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide: Colourless solid,m.p. 132-133 °C (lit.7 129-130 °C); 1H NMR (400 MHz, CDCl3):δ 3.26 (s, 3H), 7.83 (m, 2H), 7.93 (dd, J = 7.2, 1.6 Hz, 1H), 8.05 (dd,J = 7.2, 1.6 Hz, 1H). 13C NMR (100 MHz, CDCl3): δ 23.2, 120.9,125.1, 127.5, 134.3, 134.6, 137.5, 158.6.

References:

Wang, Xiaolong;Ma, Yanying;Ju, Tingting [Journal of Chemical Research,2013,vol. 37,# 7,p. 417 - 419]

2527-66-4 Synthesis