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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Nalidixic acid

Nalidixic acid synthesis

9synthesis methods
Nalidixic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthiridin-3- carboxylic acid (33.2.4), is synthesized by the following scheme. In the first stage, the reaction of 2-amino-6-methylpyridine and diethyl ethoxymethylenemalonate forms the substituted product (33.2.1), which when heated cyclizes to ethyl ester of 4-hydroxy -7-methyl-1,8-napthiridin-3-carboxylic acid (33.2.2). Hydrolyzing the resulting product with a base gives the corresponding acid (33.2.3). Alkylating this with ethyl iodide in the presence of potassium hydroxide gives nalidixic acid.

2-Amino-6-methylpyridine

1824-81-3
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$8.00/25g

Nalidixic acid

389-08-2
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$10.00/1g

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[N-Ethyl-N-(6-methyl-2-pyridyl)amino]methylenemalonic acid diethyl ester

34748-19-1
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Nalidixic acid

389-08-2
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References
ethyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate

33331-59-8
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Nalidixic acid

389-08-2
368 suppliers
$10.00/1g

References
Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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Nalidixic acid

389-08-2
368 suppliers
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References
diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate

13250-95-8
29 suppliers
$32.29/1g

Nalidixic acid

389-08-2
368 suppliers
$10.00/1g

References

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