Parathion synthesis
- Product Name:Parathion
- CAS Number:56-38-2
- Molecular formula:C10H14NO5PS
- Molecular Weight:291.26
Yield:56-38-2 83%
Reaction Conditions:
in tetrahydrofuran at -5 - 0; for 1 h;
Steps:
AAT AAT. 1-(4-Acetylpiperazin-1-yl)butane-1,3-dione
AAT. 1-(4-Acetylpiperazin-1-yl)butane-1,3-dione
A solution of 20.8 g (0.17 mol) 1-acetylpiperazine in 50 ml tetrahydrofuran were added dropwise to a solution of 13 g of diketene (0.16 mol) in 200 ml tetrahydrofuran at -5 to 0° C.
After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography.
The reaction mixture was evaporated and the residue purified by column chromatography.
This gave 27.2 g (0.13 mol, 83% yield) of a colorless oil.
IR (neat, cm-1): 2919, 2864, 1718, 1631, 1422, 1358, 1307, 1284, 1248, 1159, 1063, 993.
LC-MS: 213 (M+H), 235 (M+Na).
1H-NMR (CDCl3, 400 MHz): δ [ppm]=3.6 (6H), 3.4 (3H), 3.3 (1H), 2.2 (3H), 2.1 (3H).
References:
Vifor (International) AG;Bark, Thomas;Buhr, Wilm;Burckhardt, Susanna;Burgert, Michael;Canclini, Camillo;Dürrenberger, Franz;Funk, Felix;Geisser, Peter;Kalogerakis, Aris;Mayer, Simona;Philipp, Erik;Reim, Stefan;Sieber, Diana;Schmitt, Jörg;Schwarz, Katrin US2013/109662, 2013, A1 Location in patent:Paragraph 0568; 0569; 0570; 0571; 0572
