PHENYLPYRIDYLMETHYL ACETATE synthesis
- Product Name:PHENYLPYRIDYLMETHYL ACETATE
- CAS Number:26483-64-7
- Molecular formula:C14H13NO2
- Molecular Weight:227.26
1658-42-0
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108-86-1
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26483-64-7
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$108.00/100mg
Yield:26483-64-7 97%
Reaction Conditions:
with palladium diacetate;caesium carbonate;XPhos in 1,4-dioxane at 100; for 12 h;Inert atmosphere;Schlenk technique;
Steps:
1.2 General procedure for the arylation reaction
General procedure: An oven-dried Schlenk tube was charged with Pd(OAc)2 (0.015 mmol, 3.4 mg), X-Phos (0.015 mmol, 7.2 mg), Cs2CO3 (0.9 mmol, 293 mg), substrate 1 (0.3 mmol) and 2 (0.4 mmol). The reaction vessel was evacuated and backfilled again with nitrogen gas, and 1,4-dioxane (1 mL) was added via syringe under nitrogen. The reaction mixture was stirred at 100 °C for 12 hours. The reaction mixture was then cooled to room temperature and diluted with EtOAc. The crude was nextfiltered through a plug of celite, which was washed with ethyl acetate. The solution was concentrated and further purifiedby flash column chromatography to afford the corresponding product.
References:
Jin, Chaochao;Xu, Kun;Fan, Xiao;Liu, Changyao;Tan, Jiajing [Chinese Chemical Letters,2020,vol. 31,# 1,p. 91 - 94] Location in patent:supporting information
67-56-1
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5005-36-7
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26483-64-7
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$108.00/100mg
67-56-1
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39930-11-5
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201230-82-2
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26483-64-7
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140-29-4
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26483-64-7
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109-04-6
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26483-64-7
26 suppliers
$108.00/100mg