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Pyrazin-2-yl-acetic acid ethyl ester synthesis

3synthesis methods
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Yield:1060815-23-7 63%

Reaction Conditions:

Stage #1: 2-Methylpyrazinewith n-butyllithium;N-ethyl-N,N-diisopropylamine in tetrahydrofuran;hexane at -78; for 0.5 h;Inert atmosphere;
Stage #2: Diethyl carbonate in tetrahydrofuran;hexane; for 2 h;Inert atmosphere;

References:

Han, Chunyu;Liu, Yaowen;Tian, Xianhai;Rominger, Frank;Hashmi, A. Stephen K. [Organic Letters,2021,vol. 23,# 24,p. 9480 - 9484] Location in patent:supporting information