ChemicalBook CAS DataBase List Safrole

Safrole synthesis

11synthesis methods

Product Name:Safrole
CAS Number:94-59-7
Molecular formula:C10H10O2
Molecular Weight:162.19

By distillation and/or freezing of such oils as Cinnamomum micranthum, Octea cymharum and oil of sassafras.

274-09-9
461 suppliers
$5.00/5g

107-18-6
2 suppliers
$24.60/100ml

94-59-7
2 suppliers
$29.00/10mg

120-58-1
2 suppliers
$65.00/1mg

Yield:94-59-7 80%

Reaction Conditions:

with Nafion-H resin at 20;Friedel-Crafts Alkylation;

Steps:

General procedure
Nafion-H (14.65 g, 10 % wt. % based on the 1,2-methylene-dioxybenzene was used) was added to the mixture of 1,2-methylenedioxybenzene (146.54 g, 1.2 mol) and allyl alcohol (2.33 g, 0.04 mol) and stirred at room temperature until the allyl alcohol is disappeared. The Nafion-H catalyst was filtered off. Excess 1,2-methylenedioxybenzene was removed under reduced pressure. The crude product was vacuum distilled, 5.19 g of safrole, boiling at 120-130 °C (10-15 mm Hg), was obtained. Colourless and typically smelling oil. Total yield (from the allyl alcohol), 80 % of theory.

References:

Ou, Wenhua;Huang, Hong [Asian Journal of Chemistry,2015,vol. 27,# 3,p. 1175 - 1176]

FullText

94839-07-3 Synthesis