ChemicalBook CAS DataBase List tert-Butyl 3-bromopropylcarbamate

tert-Butyl 3-bromopropylcarbamate synthesis

10synthesis methods

Product Name:tert-Butyl 3-bromopropylcarbamate
CAS Number:83948-53-2
Molecular formula:C8H16BrNO2
Molecular Weight:238.12

24424-99-5 Synthesis

24424-99-5
863 suppliers
$13.50/25G

5003-71-4 Synthesis

5003-71-4
388 suppliers
$5.00/10g

83948-53-2
205 suppliers
$6.00/1g

Yield:83948-53-2 98%

Reaction Conditions:

with triethylamine in dichloromethane;ethyl acetate

Steps:

R.4 Synthesis of Boc-aminopropyl bromide:
Reference Example 4 Synthesis of Boc-aminopropyl bromide: In 20 ml of dichloromethane, 1.222 g (5.58 mmol) of 3-bromopropylamine hydrobromide was dissolved, 0.778 ml (5.58 mmol) of triethylamine was added thereto under ice-cooling, and 50 ml dichloromethane solution of 1.214 g (5.56 mmol) of Boc₂O was further added dropwise thereto in 10 minutes, followed by stirring. After stirring at room temperature for 50 minutes, ethyl acetate was added thereto, followed by separation by washing with 5% aqueous citric acid solution, water and saturated brine consecutively. After dehydration with sodium sulfate, the solvent was evaporated under reduced pressure to give 1.304 of the titled compound (98%). The structure was identified by ¹H-NMR. ¹H-NMR (500 MHz,CDCl₃) δ (ppm) = 1.44 (9H, s, Boc), 2.05 (2H, quant, -NHCH₂CH₂CH₂Br), 3.28 (2H, q, -NHCH₂CH₂CH₂Br), 3.44 (2H, t, -NHCH₂CH₂CH₂Br), 4.64 (1H, s, NH)