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ChemicalBook CAS DataBase List Valaciclovir

Valaciclovir synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere
1.2: 20 - 50 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / Cooling with ice

References:

Chen, Yong;Alberti, Ingo;Kalia, Yogeshvar N. [European Journal of Pharmaceutics and Biopharmaceutics,2016,vol. 99,p. 103 - 113]

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