Z-VAL-OSU synthesis
- Product Name:Z-VAL-OSU
- CAS Number:3496-11-5
- Molecular formula:C17H20N2O6
- Molecular Weight:348.35
6066-82-6
1149-26-4
3496-11-5
Step 1. To a stirred solution of N-hydroxybutanediimide (1 g, 4 mmol) and CBZ-L-valine (459 mg, 4 mmol) in tetrahydrofuran (THF, 20 mL) was added N,N'-dicyclohexylcarbodiimide (DCC, 908 mg, 4.4 mmol) at 0° C. The reaction was carried out at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to afford (S)-2,5-dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (yield: 90%).
72-18-4
881 suppliers
$5.00/25g
3496-11-5
122 suppliers
$9.00/1g
Yield:-
Steps:
Multi-step reaction with 2 steps
1: sodium carbonate / water / 16 h / 28 °C
2: dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 0 - 20 °C
References:
GENENTECH, INC.;THE UNIVERSITY OF AUCKLAND;LEE, Ho Huat;TERCEL, Moana;FLYGARE, John A.;GUNZNER-TOSTE, Janet;PILLOW, Thomas H.;SAFINA, Brian;STABEN, Leanna;VERMA, Vishal;WEI, BinQing;ZHAO, Guiling WO2015/95227, 2015, A2
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
501-53-1
409 suppliers
$10.00/1g
3496-11-5
122 suppliers
$9.00/1g
