Ascorbate
- CAS No.
- 50-81-7
- Chemical Name:
- Ascorbate
- Synonyms
- ASCORBIC ACID;VITAMIN C;L-ASCORBIC ACID;Ascorbate;ascorbic;L-ASCORBATE;(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one;ASCOBIC ACID;3-Keto-L-gulofuranolactone;Ascorb
- CBNumber:
- CB00130647
- Molecular Formula:
- C6H8O6
Lewis structure
- Molecular Weight:
- 176.12
- MDL Number:
- MFCD03457784
- MOL File:
- 50-81-7.mol
- MSDS File:
- SDS
| Melting point | 190-194 °C (dec.) |
|---|---|
| alpha | 20.5 º (c=10,H2O) |
| Boiling point | 227.71°C (rough estimate) |
| Density | 1,65 g/cm3 |
| FEMA | 2109 | ASCORBIC ACID |
| refractive index | 21 ° (C=10, H2O) |
| storage temp. | Store at +5°C to +30°C. |
| solubility | H2O: 50 mg/mL at 20 °C, clear, nearly colorless |
| form | powder |
| pka | 4.04, 11.7(at 25℃) |
| color | white to slightly yellow |
| PH | 3.59(1 mM solution);3.04(10 mM solution);2.53(100 mM solution); |
| Odor | Odorless |
| PH Range | 1 - 2.5 |
| optical activity | [α]25/D 19.0 to 23.0°, c = 10% in H2O |
| Odor Type | green |
| Water Solubility | 333 g/L (20 ºC) |
| Merck | 14,830 |
| BRN | 84272 |
| BCS Class | 1 |
| Stability | Stable. May be weakly light or air sensitive. Incompatible with oxidizing agents, alkalies, iron, copper. |
| InChIKey | CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
| LogP | -1.85 |
| Substances Added to Food (formerly EAFUS) | ASCORBIC ACID |
| SCOGS (Select Committee on GRAS Substances) | L-Ascorbic acid |
| FDA 21 CFR | 101.9; 104.20; 310.545 |
| CAS DataBase Reference | 50-81-7(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | ascorbic acid; vitamin C |
| FDA UNII | PQ6CK8PD0R |
| NCI Drug Dictionary | ascorbic acid |
| ATC code | G01AD03,S01XA15 |
| NIST Chemistry Reference | L-Ascorbic acid(50-81-7) |
| EPA Substance Registry System | Ascorbic acid (50-81-7) |
| Cosmetics Info | Ascorbic Acid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338-P370+P378 | |||||||||
| Hazard Codes | ||||||||||
| Risk Statements | ||||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CI7650000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29362700 | |||||||||
| Toxicity | LD50 oral in rat: 11900mg/kg | |||||||||
| NFPA 704 |
|
Ascorbate price More Price(135)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V-038 | L-Ascorbic acid solution 1.0?mg/mLinacetonitrile:water,certifiedreferencematerial,Cerilliant? | 50-81-7 | 1mL | $82.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB2100872 | Anti-GAA antibody produced in rabbit affinity isolated antibody | 50-81-7 | 100μL | $524 | 2024-03-01 | Buy |
| Sigma-Aldrich | HPA029126 | Anti-GAA antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 50-81-7 | 100μL | $547 | 2024-03-01 | Buy |
| Sigma-Aldrich | HPA026970 | Anti-GAA antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 50-81-7 | 100μL | $547 | 2024-03-01 | Buy |
| Sigma-Aldrich | AX1775 | Ascorbic Acid Meets ACS Specifications GR ACS | 50-81-7 | 100g | $151 | 2024-03-01 | Buy |
Ascorbate Chemical Properties,Uses,Production
Description
Ascorbate is the metabolite of vitamin C actually used within the body and thus the preferable form of vitamin C.
Uses
Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. However, it also has a number of other important functions, participating as a co-factor in several enzyme reactions including catecholamine synthesis, collagen production and regulation of HIF-1α.
Application
Ascorbate is the superior form of vitamin C for several reasons:
Ascorbate is the physiological form of vitamin C used by the body.
Ascorbate is the form of vitamin C that serves as the most powerful water-soluble antioxidant.
Ascorbate can have different qualities. First, it can be “fully reduced," which means its electrons are all in place and ready to be donated for full antioxidant activity. “Fully reduced” means that it is not already oxidized, even partially. To be “fully reduced” the ascorbate must be processed without exposure to oxygen, light or excess heat.
Second, ascorbate can also be “fully buffered.” A “fully buffered” ascorbate is one that has been combined with small amounts of selected minerals (for example, calcium, magnesium, zinc, potassium). “Fully buffered” ascorbate reduces metabolic acidity and contributes to a life-supporting, slightly alkaline tissue pH.
Mechanism of action
Ascorbate is transported into the brain and neurons via the Sodium-dependent Vitamin C Transporter-2 (SVCT2), which causes accumulation of ascorbate within cells against a concentration gradient. Dehydroascorbic acid, the oxidized form of ascorbate, is transported via glucose transporters of the GLUT family. Once in cells, it is rapidly reduced to ascorbate. The highest concentrations of ascorbate in the body are found in the brain and neuroendocrine tissues such as adrenal, although the brain is the most difficult organ to deplete of ascorbate. Combined with regional asymmetry in ascorbate distribution within different brain areas, these facts suggest an important role for ascorbate in the brain. Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors. Neurodegenerative diseases typically involve high levels of oxidative stress and thus ascorbate has been posited to have potential therapeutic roles against ischemic stroke, Alzheimer's disease, Parkinson's disease and Huntingdon's disease.
Ascorbate Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 | info@nxjhchem.com | China | 79 | 58 |
| TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD | +86-576-88902229;+86-0576-88902229 +8613968687450 | yuxin@yuxchem.com | China | 122 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 1000 | 58 |
| Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +8613864437655 | ziboweibinmaoyi@163.com | China | 100 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 | sales@suikangpharm.com | China | 179 | 58 |
| Hebei Dongdu Import and Export Co. LTD | +86-15333296769 +86-15333296769 | manager@cndongdu.com | China | 71 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 | admin@china-yime.com | China | 563 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
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View Lastest Price from Ascorbate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-01-31 | Tetrahexyldecyl ascorbate
183476-82-6
|
US $100.00 / KG | 1KG | 99% | 5000kg/week | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-01-12 | Sodium ascorbate
134-03-2
|
US $1.00 / KG | 1KG | 98%min | 10ton/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-11-15 | Calcium Ascorbate
5743-28-2
|
US $90.00 / KG | 500KG | 99.9% | 100tons | Qiuxian Baitai New Material Co., LTD |
-
- Tetrahexyldecyl ascorbate
183476-82-6
- US $100.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Sodium ascorbate
134-03-2
- US $1.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Calcium Ascorbate
5743-28-2
- US $90.00 / KG
- 99.9%
- Qiuxian Baitai New Material Co., LTD