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4-Benzylpiperidine

4-Benzylpiperidine structure

CAS No.: 31252-42-3

Chemical Name:: 4-Benzylpiperidine

Synonyms: NSC 30346;AKOS BBS-00003617;4-Benzylpiperdine;4-benzyl-piperidin;4-BENZYLPIPERIDINE;Piperidine, 4-benzyl-;4-Benzylpiperidine99%;LABOTEST-BB LTBB000752;4-Benzylpiperidine,98%;4-Benzylpiperidine >

CBNumber:: CB9141122

Molecular Formula:: C12H17N

Molecular Weight:: 175.27

MDL Number:: MFCD00006006

MOL File:: 31252-42-3.mol

MSDS File:: SDS

Last updated:2023-04-27 16:27:43

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4-Benzylpiperidine Properties

Melting point	6-7 °C (lit.)
Boiling point	279 °C (lit.)
Density	0.997 g/mL at 25 °C (lit.)
refractive index	n20/D 1.537(lit.)
Flash point	>230 °F
storage temp.	Store below +30°C.
form	Viscous Liquid
pka	10.58±0.10(Predicted)
color	Clear colorless to yellow
BRN	132339
CAS DataBase Reference	31252-42-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	JDF1T4667S
EPA Substance Registry System	Piperidine, 4-(phenylmethyl)- (31252-42-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P280g-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

TM4728000

TSCA

Yes

HazardClass

IRRITANT

HS Code

29333990

NFPA 704

	1
1		0

4-Benzylpiperidine price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	142360	4-Benzylpiperidine 99%	31252-42-3	25g	$57.2	2024-03-01	Buy
TCI Chemical	B0387	4-Benzylpiperidine >99.0%(GC)	31252-42-3	25mL	$32	2022-04-27	Buy
TCI Chemical	B0387	4-Benzylpiperidine >99.0%(GC)	31252-42-3	250mL	$198	2021-12-16	Buy
Alfa Aesar	B23883	4-Benzylpiperidine, 98%	31252-42-3	100g	$91.3	2021-12-16	Buy
Alfa Aesar	B23883	4-Benzylpiperidine, 98%	31252-42-3	25g	$34.1	2021-12-16	Buy

Product number	Packaging	Price	Buy
142360	25g	$57.2	Buy
B0387	25mL	$32	Buy
B0387	250mL	$198	Buy
B23883	100g	$91.3	Buy
B23883	25g	$34.1	Buy

4-Benzylpiperidine Chemical Properties,Uses,Production

Chemical Properties

clear colourless to yellow viscous liquid.

Uses

4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

Preparation

4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

Application

Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Synthesis Reference(s)

Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196

General Description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

4-Benzylpiperidine synthesis

Synthesis of 4-Benzylpiperidine from 4-benzyl-1-[(4-methylphenyl)sulfonyl]piperidine

4-Benzylpiperidine Preparation Products And Raw materials

Raw materials

Diethylene glycol Acetic anhydride Potassium hydroxide Calcium chloride Potassium carbonate

Hydrazine hydrate Trifluoroacetic acid Sodium borohydride Aluminum chloride Tetrahydrofuran

Benzene 1,2-Dichloroethane Lithium Aluminum Hydride Hydrochloric acid Isonipecotic acid

Dichloromethane Sodium hydroxide Triethylsilane Diisopropyl ether Isopropyl alcohol

Thionyl chloride

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Preparation Products

4-Benzylpiperidine Suppliers

Global( 198)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2255	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2169	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

Supplier	Advantage
Xi'an MC Biotech, Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Changzhou Ditong Chemical Co.,Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 4-Benzylpiperidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-26	4-Benzylpiperidine 31252-42-3	US $0.00-0.00 / Kg	100G	99.0%+	100 tons	Shaanxi Dideu Medichem Co. Ltd
	2020-01-03	4-BENZYLPIPERIDINE 31252-42-3	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

4-Benzylpiperidine
31252-42-3
US $0.00-0.00 / Kg
99.0%+
Shaanxi Dideu Medichem Co. Ltd

4-BENZYLPIPERIDINE
31252-42-3
US $9.80 / KG
≥99%
Career Henan Chemical Co

4-Benzylpiperidine Spectrum

4-BENZYLPIPERIDINE(31252-42-3)MS 4-BENZYLPIPERIDINE(31252-42-3)¹HNMR 4-BENZYLPIPERIDINE(31252-42-3)¹³CNMR 4-BENZYLPIPERIDINE(31252-42-3)IR1 4-BENZYLPIPERIDINE(31252-42-3)Raman

31252-42-3(4-Benzylpiperidine)Related Search:

4-(4-FLUOROBENZOYL)PIPERIDINE P-TOLUENESULFONATE KETANSERIN TARTRATE 4-(4-Fluorobenzoyl)piperidine hydrochloride PIRENPERONE (4-METHOXYPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE

4-BENZYL-4-HYDROXYPIPERIDINE alpha,alpha-Diphenyl-4-piperidinomethanol Ifenprodil Terfenadine 4-BENZOYLPIPERIDINE HYDROCHLORIDE

BENZETIMIDE Diphenylpiperidin-4-ylmethanol hydrochloride Ketanserin 4-Benzylpiperidine 1-(2-Aminoethyl)-4-benzylpiperidine

METHYL 1-BENZYL-PIPERIDINE-3-CARBOXYLATE 4-(3-TRIFLUOROMETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE

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4-BENZYLPIPERIDINE FOR SYNTHESIS 4-(Phenylmethyl)piperidine, [(Piperidin-4-yl)methyl]benzene 4-(phenylmethyl)-piperidin 4-benzyl-piperidin LABOTEST-BB LTBB000752 PHENYL(4-PIPERIDYL)METHANE Piperidine, 4-(phenylmethyl)- Piperidine, 4-benzyl- 4-BENZYLPIPERIDINE 4-(PHENYLMETHYL)PIPERIDINE ALPHA-(4-PIPERIDYL)TOLUENE AKOS BBS-00003617 4-Benzylpiperidine99% 4-Benzylpiperidine,98% 4-Benzylpiperdine NSC 30346 4-Benzylpiperidine,4-(phenylMethyl)piperidine alpha-(Piperidin-4-yl)toluene 4-Benzylpiperidine, 98% 5GR 4-Benzylpiperidine > 4-Benzylpiperidine USP/EP/BP 31252-42-3 31252-42-4 31252-42-0 C12H18N Heterocyclic Building Blocks Piperidines Building Blocks B Bioactive Small Molecules Building Blocks C12 Cell Biology Chemical Synthesis Heterocyclic Building Blocks Piperidines Piperidine Piperidine Series