- NU1025
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- $1.00 / 1KG
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2019-07-06
- CAS:90417-38-2
- Min. Order: 1KG
- Purity: 98-100%
- Supply Ability: 1000kg
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Product Name: | NU1025 | Synonyms: | NU1025;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-Hydroxy-2-methylquinazoline-4-one ,97%;8-hydroxy-2-methyl-1H-quinazolin-4-one;NSC 696807;4(3H)-Quinazolinone, 8-hydroxy-2-Methyl- | CAS: | 90417-38-2 | MF: | C9H8N2O2 | MW: | 176.17 | EINECS: | | Product Categories: | All Inhibitors;Inhibitors;Aromatics | Mol File: | 90417-38-2.mol | |
| NU1025 Chemical Properties |
Melting point | 253-258°C | Boiling point | 345.4±44.0 °C(Predicted) | density | 1.42 | storage temp. | −20°C | solubility | DMSO: 35 mg/mL, soluble | form | solid | pka | 8.68±0.20(Predicted) | color | off-white | CAS DataBase Reference | 90417-38-2 |
Hazard Codes | Xn | Risk Statements | 22 | Safety Statements | 26 | WGK Germany | 3 | HS Code | 29335990 |
| NU1025 Usage And Synthesis |
Description | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes. | Chemical Properties | Off-White to Pale Yellow Solid | Uses | A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively. | Uses | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] | Definition | ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. | Biological Activity | Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively. |
| NU1025 Preparation Products And Raw materials |
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