| Identification | More | [Name]
4-Cyclohexylphenol | [CAS]
1131-60-8 | [Synonyms]
4-CYCLOHEXYLPHENOL
4-HYDROXYPHENYLCYCLOHEXANE
CYCLOHEXYL PHENOL
P-CYCLOHEXYLPHENOL
4-cyclohexyl-pheno
Phenol, p-cyclohexyl-
p-Hydroxyphenylcyclohexane
CYCLOHEXYLPHENOL, 4-
PARA-CYCLOHEXYLPHENOL
4-(Cyclohexane-1-yl)phenol | [EINECS(EC#)]
214-465-4 | [Molecular Formula]
C12H16O | [MDL Number]
MFCD00035699 | [Molecular Weight]
176.25 | [MOL File]
1131-60-8.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H332-H335 | [Precautionary statements ]
P280-P305+P351+P338-P310 | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HS Code ]
2907199090 |
| Hazard Information | Back Directory | [Uses]
4-Cyclohexylphenol is a derivative of Cyclohexylphenol (CHP), which is widely used in the preparation of dyes, resins, and biocides[2]. 4-Cyclohexylphenol labelled with 35s can be used for metabolic studies[3]. | [Synthesis]
4-Cyclohexylphenol is obtained by hydroalkylation of phenol using phenol as a raw material in the presence of a palladium catalyst and a molten salt (NaCl-AlCl3)[1]. The specific synthesis steps are as follows:
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.
| [References]
[1] T. KAMIYAMA; M. I; S Enomoto. Hydroalkylation of phenol to cyclohexylphenol in the presence of Pd-Al2O3 and NaCl-AlCl3 under hydrogen pressure.[J]. Chemical & pharmaceutical bulletin, 1986. DOI:10.1248/CPB.34.450.
[2] S. GUTIéRREZ-RUBIO . Synthesis of cyclohexylphenol via phenol hydroalkylation using Co2P/zeolite catalysts[J]. Catalysis Today, 2022. DOI:10.1016/j.cattod.2021.11.039.
[3] D.J. HEARSE; Gillian M P; A H Olavesen. The preparation and characterization of a series of 35S-labelled aryl sulphate esters for metabolic studies[J]. Biochemical pharmacology, 1969. DOI:10.1016/0006-2952(69)90022-7.
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