| Identification | Back Directory | [Name]
H-ARG-PHE-ALA-ARG-LYS-GLY-ALA-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN-OH | [CAS]
113731-96-7 | [Synonyms]
PKC 19-36
RFARKGALRQKNVHEVKN
PubChem ID: 71308428
PKC SELECTIVE INHIBITOR
PROTEIN KINASE C (19-36)
PROTEIN KINASE C FRAGMENT
H2N-RFARKGALRQKNVHEVKN-OH
PROTEIN KINASE C FRAGMENT 19-36
PKC SELECTIVE INHIBITOR PROTEIN
PROTEIN KINASE C (19-36) PEPTIDE
PROTEIN KINASE C SELECTIVE INHIBITOR
PROTEIN KINASE C PSEUDOSUBSTRATE (19-36)
PROTEIN KINASE C INHIBITOR PEPTIDE 19-36
PKC (19-36), PKC SELECTIVE INHIBITOR PROTEIN
Protein Kinase C Selective Inhibitor Protein
Protein Kinase C (19-36): Protein Kinase C Selective Inhibitor Protein
ARG-PHE-ALA-ARG-LYS-GLY-ALA-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN
H-ARG-PHE-ALA-ARG-LYS-GLY-ALA-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN-OH
LEU-LEU-TYR-GLU-MET-LEU-ALA-GLY-GLN-ALA-PRO-PHE-GLU-GLY-GLU-ASP-GLU-ASP-GLU-LEU-PHE-GLN-SER-ILE-MET-GLU-HIS-ASN-VAL: LLYEMLAGQAPFEGEDEDELFQSIMEHNV
L-Asparagine, L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysylglycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparaginyl-L-valyl-L-histidyl-L-α-glutamyl-L-valyl-L-lysyl- | [Molecular Formula]
C93H159N35O24 | [MDL Number]
MFCD00167619 | [MOL File]
113731-96-7.mol | [Molecular Weight]
2151.48 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [Sequence]
Arg-PheAla-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn |
| Hazard Information | Back Directory | [Uses]
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response[1]. | [References]
[1] Yasunari K, et al. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension. 1996 Aug;28(2):159-68. DOI:10.1161/01.hyp.28.2.159 |
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