| Identification | Back Directory | [Name]
scutellarin Methylester | [CAS]
119262-68-9 | [Synonyms]
Scutellarin Methlester
scutellarin Methylester
Breviscapine methyl ester
β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, methyl ester
5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid methyl ester | [EINECS(EC#)]
300-008-1 | [Molecular Formula]
C22H20O12 | [MDL Number]
MFCD29049472 | [MOL File]
119262-68-9.mol | [Molecular Weight]
476.387 |
| Chemical Properties | Back Directory | [Boiling point ]
804.0±65.0 °C(Predicted) | [density ]
1.697±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
5.92±0.40(Predicted) | [color ]
Yellow |
| Questions And Answer | Back Directory | [Effect]
The improvement effect of scutellarin methylester on ischemic brain tissue showed that scutellarin methylester can effectively improve the local cerebral blood flow of ischemia-reperfusion in rats, and significantly reduce the degree of ischemic damage to brain tissue. The mechanism may be In order to inhibit cerebral vasospasm caused by protein kinase activation, increase local cerebral blood flow, improve cerebral microcirculation, and reduce inflammatory cell adhesion and infiltration, thereby reducing brain damage. | [Mechanism of action]
Scutellarin methylester mainly inhibits the formation of thrombus in vitro through three steps, reducing platelet count, inhibiting platelet aggregation function, inhibiting coagulation function in vivo, and promoting fibrinolytic activity, of which the latter two have stronger effects. |
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