| Identification | More | [Name]
Methyl 1-Boc-3-pyrrolidinecarboxylate | [CAS]
122684-33-7 | [Synonyms]
1-TERT-BUTYL 3-METHYL PYRROLIDINE-1,3-DICARBOXYLATE
3-CARBOXY-1-BOC-PYRROLIDINE METHYL ESTER
METHYL 1-BOC-3-PYRROLIDINECARBOXYLATE
PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
TERT-BUTYL METHYL PYRROLIDINE-1,3-DICARBOXYLATE
METHYL 1-N-BOC-DL-BETA-PROLINATE
1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxylic acid methyl ester
1-(Tert-butoxycarbonyl)-3-methylpyrrolidine-3-carboxylic acid
1-Boc-3-pyrrolidine carboxylic Acid Methyl Ester | [Molecular Formula]
C11H19NO4 | [MDL Number]
MFCD04038683 | [Molecular Weight]
229.27 | [MOL File]
122684-33-7.mol |
| Questions And Answer | Back Directory | [Synthesis]
Methyl 1-benzylpyrrolidine-3-carboxylate (1.13 g) was dissolved in ethyl acetate (100 mL). Palladium on carbon (10%, 385 mg) was added to the solution, followed by di-tert-butyl dicarbonate (1.35 g, 6.18 mmol, 1.2 equivalents). The mixture was hydrogenated at room temperature for 8 hours. The suspension was filtered through diatomaceous earth, and the filtrate was concentrated under vacuum. The residue was purified by silica gel chromatography (75:25, hexane-ethyl acetate). 
Fig. Synthetic route of Methyl 1-Boc-3-pyrrolidinecarboxylate |
| Chemical Properties | Back Directory | [Boiling point ]
105℃/0.2mm | [density ]
1.120±0.06 g/cm3(Predicted) | [refractive index ]
1.4560 to 1.4600 | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
clear liquid | [pka]
-2.65±0.40(Predicted) | [color ]
Colorless to Light orange to Yellow | [InChI]
InChI=1S/C11H19NO4/c1-11(2,3)16-10(14)12-6-5-8(7-12)9(13)15-4/h8H,5-7H2,1-4H3 | [InChIKey]
LIWFYAVKYUQMRE-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(C(OC)=O)C1 | [CAS DataBase Reference]
122684-33-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to Light orange to Yellow clear liquid | [Uses]
Methyl 1-BOC-3-pyrrolidinecarboxylate is used as a synthetic intermediate. |
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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