| Identification | Back Directory | [Name]
Propargyl-PEG9-bromide | [CAS]
2055042-83-4 | [Synonyms]
Alkyne-PEG9-Br
Propargyl-PEG9-Br
Propargyl-PEG9-bromide
3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yne, 1-bromo- | [Molecular Formula]
C21H39BrO9 | [MDL Number]
MFCD29079385 | [MOL File]
2055042-83-4.mol | [Molecular Weight]
515.43 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG9-bromide consists of a propargyl group and a bromide group. The propargyl group reacts with azide compounds in copper catalyzed Click Chemistry reactions. The bromide (Br)can be used as a leaving group for nucleophilic substitution reactions. The 9-unit PEG spacer improves the hydrophilicity of the molecule. | [Uses]
Propargyl-PEG9-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG9-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2. |
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