| Identification | More | [Name]
(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE | [CAS]
132883-44-4 | [Synonyms]
(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE
(3S)-3-DIMETHYLAMINOPYRROLIDINE
(3S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE
(3S)-N,N-DIMETHYL-3-PYRROLIDINAMINE
DIMETHYL-PYRROLIDIN-3-YL-AMINE (S)
(S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE
(S)-3-(DIMETHYLAMINO) PYRROLIDINE
(S)-DIMETHYL-PYRROLIDIN-3-YL-AMINE
(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE 96+%
(S)-N,N-dimethylpyrrolidin-3-amine | [Molecular Formula]
C6H14N2 | [MDL Number]
MFCD00191348 | [Molecular Weight]
114.19 | [MOL File]
132883-44-4.mol |
| Questions And Answer | Back Directory | [Synthesis]
The synthesis of (3S)-(-)-3-(dimethylamino)pyrrolidine is currently mainly based on L-malic acid, and is synthesized through reactions such as cyclization, reduction, persulfonation and deprotection, with an overall yield of 31.45%. Its structure is directly introduced by the methylamino group using the original 3 hydroxyl groups, avoiding the construction of the chiral center of the dimethylamino group. The process of synthesizing the intermediate 6(S)-1-benzylpyrrolidine has also been optimized, with a yield of 90%. (3S)-(-)-3-(dimethylamino)pyrrolidine was synthesized with a yield of 87% through substitution and reduction, which has important reference value for the synthesis of this intermediate. The synthetic reaction formula is shown in the figure below: 
Figure 1 Synthetic reaction formula of (3S)-(-)-3-(dimethylamino)pyrrolidine This synthetic route has the advantages of simple operation, cheap and readily available raw materials, and easy separation of products, which is beneficial to the application and production of this compound. |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Boiling point ]
160 °C/760 mmHg (lit.) | [density ]
0.899 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4650(lit.)
| [Fp ]
125 °F
| [storage temp. ]
2-8°C | [form ]
clear liquid | [pka]
9.93±0.10(Predicted) | [color ]
Colorless to Light yellow | [Specific Gravity]
0.90 | [Optical Rotation]
[α]/D 14±2°, c = 1 in ethanol | [InChI]
InChI=1S/C6H14N2/c1-8(2)6-3-4-7-5-6/h6-7H,3-5H2,1-2H3/t6-/m0/s1 | [InChIKey]
AVAWMINJNRAQFS-LURJTMIESA-N | [SMILES]
N1CC[C@H](N(C)C)C1 | [CAS DataBase Reference]
132883-44-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H226-H302-H315-H318-H335 | [Precautionary statements ]
P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
Xn | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R38:Irritating to the skin.
R37:Irritating to the respiratory system. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
2
| [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
2933998090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(S)-(?)-3-(Dimethylamino)pyrrolidine can be used as a reactant in the syntheses of oxadiazolylthiazole and xanthone derivatives of biological importance. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|