| Identification | More | [Name]
DL-Menthol | [CAS]
1490-04-6 | [Synonyms]
(1RS,3RS,4SR)-4 MENTHAN-3-OL
2-ISOPROPYL-5-METHYLCYCLOHEXANOL
5-METHYL-2-(1-METHYETHYL)CYCLOHEXANOL
DL-2-ISOPROPYL-5-METHYLCYCLOHEXANOL
DL-4-MENTHAN-3-OL
DL-MENTHAN-3-OL
DL-MENTHOL
FEMA 2665
HEXAHYDROTHYMOL
HEXAHYDROTHYMOL 2-ISOPROPYL-5-METHYLCYCLOHEXANOL
(+/-)-MENTHOL
MENTHOL
MENTHOL, DL-
(+/-)-P-MENTHAN-3-OL
P-MENTHAN-3-OL
1-menthol
3-Hydroxy-p-menthane
3-p-Menthanol
5-methyl-2-(1-methylethyl)-cyclohexano
ai3-08161 | [EINECS(EC#)]
216-074-4 | [Molecular Formula]
C10H20O | [MDL Number]
MFCD00001484 | [Molecular Weight]
156.27 | [MOL File]
1490-04-6.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless crystals | [Melting point ]
34-36 °C(lit.)
| [Boiling point ]
216 °C(lit.)
| [density ]
0.89 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.8 mm Hg ( 20 °C)
| [FEMA ]
2665 | MENTHOL RACEMIC | [Fp ]
200 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Very soluble in ethanol (95%), chloroform, ether, fatty
oils and liquid paraffin; freely soluble in glacial acetic acid;soluble in acetone and benzene; very slightly soluble in glycerin;
practically insoluble in water. | [form ]
neat | [pka]
15.30±0.60(Predicted) | [color ]
Clear Colourless | [Odor]
at 10.00 % in dipropylene glycol. cooling mentholic minty | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Odor Type]
mentholic | [JECFA Number]
427 | [Henry's Law Constant]
3.1×10-1 mol/(m3Pa) at 25℃, Ebert et al. (2023) | [Dielectric constant]
3.2（Ambient） | [Major Application]
pharmaceutical (small molecule) | [Cosmetics Ingredients Functions]
REFRESHING
FRAGRANCE
DENATURANT
SOOTHING | [InChI]
1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3 | [InChIKey]
NOOLISFMXDJSKH-UHFFFAOYSA-N | [SMILES]
OC1C(CCC(C1)C)C(C)C | [LogP]
3.3-3.79 at 25℃ | [Uses]
menthol is a fragrance. It is also said to be anti-septic, cooling, refreshing, and a blood-circulation stimulant. Menthol gives the skin a “cool” feeling after use. It constitutes almost 50 percent of peppermint oil but can also be synthetically produced through the hydrogenation of thymol. It is non-toxic in low doses, but in high concentrations it can be irritating to the skin, especially the mucous membranes. | [CAS DataBase Reference]
1490-04-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Menthol(1490-04-6) | [EPA Substance Registry System]
1490-04-6(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H315-H318-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed .
R40:Limited evidence of a carcinogenic effect.
R22:Harmful if swallowed. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 1888 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
OT0525000
| [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HS Code ]
29061100 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 | [Hazardous Substances Data]
1490-04-6(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
colourless crystals | [Chemical Properties]
Racemic menthol is a mixture of equal parts of the (1R,2S,5R)- and
(1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated
crystalline powder, or colorless, prismatic, or acicular shiny crystals,
or hexagonal or fused masses with a strong characteristic odor and
taste. The crystalline form may change with time owing to
sublimation within a closed vessel. The USP 32 specifies that
menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and
PhEur 6.0, along with other pharmacopeias, include two separate
monographs for racemic and l-menthol. | [Definition]
A white crystalline terpenealcohol, C10H19OH; r.d. 0.89;m.p. 42°C; b.p. 103–104°C. It has aminty taste and is found in certainessential oils (e.g. peppermint) andused as a flavouring. | [Definition]
ChEBI: Any secondary alcohol that is one of the eight possible diastereoisomers of 5-methyl-2-(propan-2-yl)cyclohexan-1-ol. | [Production Methods]
Menthol occurs widely in nature as l-menthol and is the principal
component of peppermint and cornmint oils obtained from the
Mentha piperita and Mentha arvensis species. Commercially, lmenthol
is mainly produced by extraction from these volatile oils. It
may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of
routes, e.g. by hydrogenation of thymol. | [Brand name]
Fisherman’s Friend
Lozenges (Bristol-Myers Products); Therapeutic Mineral
Ice (Bristol-Myers Products). | [Pharmaceutical Applications]
Menthol is widely used in pharmaceuticals, confectionery, and
toiletry products as a flavoring agent or odor enhancer. In addition
to its characteristic peppermint flavor, l-menthol, which occurs
naturally, also exerts a cooling or refreshing sensation that is
exploited in many topical preparations. Unlike mannitol, which
exerts a similar effect due to a negative heat of solution, l-menthol
interacts directly with the body’s coldness receptors. d-Menthol has
no cooling effect, while racemic menthol exerts an effect approximately
half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in
ethanol (95%) and sprayed onto tablet granules and not used as a
solid excipient.
Menthol has been investigated as a skin-penetration enhancer
and is also used in perfumery, tobacco products, chewing gum and
as a therapeutic agent. When applied to the skin, menthol dilates the
blood vessels, causing a sensation of coldness followed by an
analgesic effect. It relieves itching and is used in creams, lotions, and
ointments. When administered orally in small doses menthol has a
carminative action. | [Safety]
Almost all toxicological data for menthol relate to its use as a
therapeutic agent rather than as an excipient. Inhalation or
ingestion of large quantities can result in serious adverse reactions
such as ataxia and CNS depression,hypersensitivity reactions,
severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and
coma.Although menthol is essentially nonirritant there have been
some reports of hypersensitivity following topical application.
In a Polish study approximately 1% of individuals were determined
as being sensitive to menthol.There have been reports of apnea
and instant collapse in infants after the local application of menthol
to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to
0.4 mg/kg body-weight.
LD50 (rat, IM): 10.0 g/kg
LD50 (rat, oral): 3.18 g/kg | [storage]
A formulation containing menthol 1% w/w in aqueous cream has
been reported to be stable for up to 18 months when stored at room
temperature.
Menthol should be stored in a well-closed container at a
temperature not exceeding 25°C, since it sublimes readily. | [Incompatibilities]
Incompatible with: butylchloral hydrate; camphor; chloral hydrate;
chromium trioxide; b-naphthol; phenol; potassium permanganate;
pyrogallol; resorcinol; and thymol. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (dental
preparations, inhalations, oral aerosols, capsules, solutions, suspensions,
syrups, and tablets; also topical preparations). Included in
nonparenteral medicines licensed in the UK. Accepted for use in
foods and confectionery as a flavoring agent of natural origin.
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
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