| Identification | More | [Name]
4-BROMO-2-CHLOROBENZONITRILE | [CAS]
154607-01-9 | [Synonyms]
4-BROMO-2-CHLOROBENZONITRILE
2-CHLORO-4-BROMOBENZONITRILE
| [EINECS(EC#)]
679-039-6 | [Molecular Formula]
C7H3BrClN | [MDL Number]
MFCD00040883 | [Molecular Weight]
216.46 | [MOL File]
154607-01-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
67-68°C | [Boiling point ]
142-143°C 10mm | [density ]
1.74±0.1 g/cm3(Predicted) | [Fp ]
142-143°C/10mm | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
White to Almost white | [BRN ]
3240885 | [InChI]
InChI=1S/C7H3BrClN/c8-6-2-1-5(4-10)7(9)3-6/h1-3H | [InChIKey]
AYQBMZNSJPVADT-UHFFFAOYSA-N | [SMILES]
C(#N)C1=CC=C(Br)C=C1Cl | [LogP]
3.14 | [CAS DataBase Reference]
154607-01-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H302-H311-H315-H319-H332 | [Precautionary statements ]
P280h-P305+P351+P338-P309-P310 | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3439 | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
2926907090 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white crystalline | [Uses]
Used as a intermediate in organic synthesis and a ligand in transition metal complexes. | [Application]
4-Bromo-2-chlorobenzonitrile is used as a pharmaceutical intermediate in oncology research. This compound is used in the preparation of darolutamide, a non-steroidal antiandrogenic drug used in the treatment of non-metastatic and metastatic castration-resistant prostate cancer. | [Synthesis]
4-Bromo-2-chlorobenzonitrile is prepared by a two-step reaction of reacting 4-bromo-2-chlorobenzaldehyde and sodium cyanide in aqueous solution. | [References]
[1] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 539 - 552 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|