| Identification | Back Directory | [Name]
mPEG8-Alkyne | [CAS]
880081-81-2 | [Synonyms]
mPEG8-Alkyne
mPEG11-Alkyne
MPEG8-PROPYNE
m-PEG8-O-alkyne
m-PEG9-Propargyl
2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne | [Molecular Formula]
C20H38O9 | [MDL Number]
MFCD31656935 | [MOL File]
880081-81-2.mol | [Molecular Weight]
422.51 |
| Chemical Properties | Back Directory | [Boiling point ]
468.8±40.0 °C(Predicted) | [density ]
1.057±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG8-O-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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