| Identification | More | [Name]
4-(4-Methylpiperazino)aniline | [CAS]
16153-81-4 | [Synonyms]
1-(4-AMINOPHENYL)-4-METHYLPIPERAZINE
4-(4-METHYLPIPERAZIN-1-YL)ANILINE
4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINE
4-(4-METHYLPIPERAZINE)ANILINE
4-(4-METHYLPIPERAZINO)ANILINE
AKOS B021941
AKOS BB-8657
ART-CHEM-BB B021941
OTAVA-BB BB7110920492
4-(4-Methyl-1-piperazinyl)aniline
4-Methyl-1-(4-aminophenyl)piperazine
Benzenamine, 4-(4-methyl-1-piperazinyl)-(9CI)
1-(4-Aminophenyl)-4-methylpipe
4-Methyl-1-(4-Aminophenyl)Pipe
4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINE 98%
4-(4-methylpiperazin-1-yl)benzenamine
4-(4-Methyl-1-piperazino)aniline, 97%
4-(4-methylpiperazino)phenylamine | [Molecular Formula]
C11H17N3 | [MDL Number]
MFCD00172703 | [Molecular Weight]
191.27 | [MOL File]
16153-81-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
89 °C | [Boiling point ]
180°C/5mmHg(lit.) | [density ]
1.092±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
8.08±0.42(Predicted) | [color ]
Very Dark Gray to Black | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3 | [InChIKey]
MOZNZNKHRXRLLF-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(N2CCN(C)CC2)C=C1 | [CAS DataBase Reference]
16153-81-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3259 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
Purple solid | [Uses]
4-(4-Methylpiperazino)aniline is a reagent in the preparation of benzyloxypyridinone derivative which has c-Met kinase inhibitor properties. | [Synthesis]
GENERAL METHOD: 1-methyl-4-(4-nitrophenyl)piperazine (5.53 mmol) was dissolved in methanol (15 mL) and stirred under N2 atmosphere. Pd/C (2.78 mmol) was added to this solution. Subsequently, the reaction flask was placed in H2 atmosphere (balloon) for hydrogenation reaction overnight. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plate and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography (eluent: 5% MeOH/DCM containing 1% NH3) to afford the target compound 4-(4-methyl-1-piperazinyl)aniline (3a) as a brown solid in 87% yield. | [References]
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[2] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 896 - 905
[3] Patent: US6569878, 2003, B1
[4] Patent: EP1215208, 2002, A2. Location in patent: Example C(70)
[5] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 58; 59 |
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