| Identification | More | [Name]
DIETHYLCARBAMAZINE CITRATE | [CAS]
1642-54-2 | [Synonyms]
DIETHYLCARBAMAZINE CITRATE
DIETHYLCARBAMAZINE CITRATE SALT
N,N-DIETHYL-4-METHYL-1-PIPERAZINECARBOXAMIDE CITRATE
N,N-DIETHYL-4-METHYL-1-PIPERAZINECARBOXAMIDE CITRATE SALT
N,N-DIETHYL-4-METHYL-L-PIPERAZINECARBOXAMIDE CITRATE SALT
1-diethylcarbamoyl-4-methylpiperazinedihydrogencitrate
1-diethylcarbamoyl-4-methylpiperazinedihydrogencitrate[qr]
1-methyl-4-diethylcarbamoylpiperazinecitrate
1-methyl-4-diethylcarbamoylpiperazinecitrate[qr]
1-piperazinecarboxamide,n,n-diethyl-4-methyl-,2-hydroxy-1,2,3-propanetricar
1-piperazinecarboxamide,n,n-diethyl-4-methyl-,2-hydroxy-1,2,3-propanetricarbo
banocide[qr]
caritrol
caritrol[qr]
carricidecitrate
dicarocide
dicarocide[qr]
diethylcarbamazanecitrate
diethylcarbamazanecitrate[qr]
diethylcarbamazineacidcitrate | [EINECS(EC#)]
216-696-6 | [Molecular Formula]
C16H29N3O8 | [MDL Number]
MFCD00039124 | [Molecular Weight]
391.42 | [MOL File]
1642-54-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [Melting point ]
140 °C | [Boiling point ]
516.39°C (rough estimate) | [density ]
1.1718 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Very soluble in water, soluble in ethanol (96 per cent), practically insoluble in acetone. | [form ]
powder | [color ]
White to Almost white | [Water Solubility ]
almost transparency | [Usage]
Can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg | [BRN ]
3836352 | [BCS Class]
1 | [InChI]
1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) | [InChIKey]
PGNKBEARDDELNB-UHFFFAOYSA-N | [SMILES]
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1 | [CAS DataBase Reference]
1642-54-2(CAS DataBase Reference) | [EPA Substance Registry System]
Diethylcarbamazine citrate (1642-54-2) |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R22:Harmful if swallowed.
R26:Very Toxic by inhalation. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
TL1225000
| [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2933595960 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Acute Tox. 4 Oral | [Safety Profile]
Poison by inhalation
and intravenous routes. Moderately toxic by
ingestion, subcutaneous, and intraperitoneal
routes. An experimental teratogen. When
heated to decomposition it emits toxic
fumes of NOx. | [Hazardous Substances Data]
1642-54-2(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 1.38 g/kg (Harned) |
| Hazard Information | Back Directory | [General Description]
Crystalline solid, scored white tablets. Used against filariasis in man and animals. | [Health Hazard]
(Non-Specific--Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects. | [Fire Hazard]
When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat. | [Description]
Diethylcarbamazine citrate is an odorless,white crystalline powder; Molecular weight=391.48;Freezing/Melting point=135-143℃. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 1, Reactivity 0. Soluble in water. | [Chemical Properties]
White or almost white, crystalline powder, slightly hygroscopic. | [Originator]
Hetrazan,Lederle,US,1949 | [Uses]
Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg. | [Definition]
ChEBI: Diethylcarbamazine citrate is a piperazinecarboxamide. | [Manufacturing Process]
To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochloride
and 8.34 grams of sodium hydroxide. When solution had been effected the
beaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxide
dissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride were
added simultaneously. When all had been added, the solution was extracted 3
times with ether which was then dried and filtered. The ether solution was
saturated with dry hydrogen chloride. A yellow gum appeared which on
trituration gave a white, hygroscopic solid which was filtered and dried in a
drying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamide
hydrochloride had a melting point of 150°-155°C.
If the compound itself is desired, the salt is dissolved in water and the
solution saturated with a mild alkali such as potassium carbonate. The product
is then extracted with chloroform, dried, and after removal of the chloroform,
distilled.
| [Therapeutic Function]
Anthelmintic | [Potential Exposure]
Used against filariasis in humans andanimals. Especially popular in veterinary medicine(anthelmintic). | [Veterinary Drugs and Treatments]
Once the hallmark agent for heartworm disease prophylaxis in dogs,
DEC is no longer commercially available in the USA (in oral veterinary
dosage forms). DEC is approved for use for the prophylaxis of
heartworm
disease (D. immitis), and/or the treatment of ascariasis
in dogs. The drug is also used in ferrets and zoo animals susceptible
to heartworm. DEC is used in dogs at higher dosages as alternative
therapy
for several other parasites (see Dosage section below). Some
products were labeled for use in cats to treat ascarid infections.
In cats, DEC may help alleviate the course (preventing lymphoma
development) of FeLV infection.
In the U.K., DEC is used as an injectable product to control parasitic
bronchitis (Dictyocaulus viviparous) in sheep and cattle.
In humans, DEC is indicated as a filaricidal for the treatment
of Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocerca
volvulus. | [First aid]
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. | [Shipping]
Medicine, solid, toxic, n.o.s. requires a label of“POISONOUS/TOXIC MATERIALS.” They fall in HazardClass 6.1. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
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| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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