| Identification | More | [Name]
2-Chloro-4-methoxypyridine | [CAS]
17228-69-2 | [Synonyms]
2-CHLORO-4-METHOXYPYRIDINE
IFLAB-BB F1957-0003 | [EINECS(EC#)]
625-435-9 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD02093951 | [Molecular Weight]
143.57 | [MOL File]
17228-69-2.mol |
| Chemical Properties | Back Directory | [Boiling point ]
224-225 °C (lit.) | [density ]
1.258 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5400(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in alcohol. | [form ]
Liquid | [pka]
2.25±0.10(Predicted) | [color ]
Colorless to pale yellow | [Specific Gravity]
1.258 | [BRN ]
1423379 | [InChI]
InChI=1S/C6H6ClNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3 | [InChIKey]
PMTPFBWHUOWTNN-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC(OC)=C1 | [CAS DataBase Reference]
17228-69-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2810 | [WGK Germany ]
3
| [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Uses]
2-Chloro-4-methoxypyridine may be used to synthesize:
- 2-(2′,4′-difluorophenyl)-4-methoxypyridine
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate
| [Uses]
It is an active pharmaceutical ingredient. | [General Description]
2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide. | [Synthesis]
At room temperature, 4-tert-butylpyridine (5.5 mL, 5.08 g, 37.5 mmol, Aldrich) was dissolved in acetic acid (30 )
mL, Fluka). Hydrogen peroxide was added (30% aqueous solution, 11.5 mL, containing 3.83 g H2O2, 113
mmol, excess, Fluka.). The reaction mixt |
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