| Identification | More | [Name]
4-Amino-3-chlorophenol | [CAS]
17609-80-2 | [Synonyms]
4-AMINO-3-CHLOROPHENOL
AMINO(4-)-3-CHLOROPHENOL
3-chloro-4-aminophenol
4-amino-3-chloro-pheno | [EINECS(EC#)]
241-583-3 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD00801116 | [Molecular Weight]
143.57 | [MOL File]
17609-80-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
159-160℃ | [Boiling point ]
287.3±25.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [RTECS ]
SJ5710000 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
9.26±0.18(Predicted) | [color ]
White | [Stability:]
Hygroscopic | [CAS DataBase Reference]
17609-80-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Uses]
4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment. | [Application]
The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like. | [Synthesis]
Starting from o-chloronitrobenzene with the introduction of hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Beside, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling could synthesize 4-Amino-3-chlorophenol. |
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