| Identification | More | [Name]
5,5'-DIMETHYL-2,2'-DIPYRIDYL | [CAS]
1762-34-1 | [Synonyms]
5,5-DIMETHYL-2,2-BIPYRIDINE
5,5'-DIMETHYL-2,2'-BIPYRIDYL
5,5'-DIMETHYL-2,2'-DIPYRIDYL
5,5-DIMETHYL-2,2-DIPYRIDYL
6,6'-BI-3-PICOLINE
6,6'-DI-3-PICOLINE
6,6'-DI-3-PICOLYL
5,5’-dimethyl-2’-bipyridine
5,5-Dimethyl-2,2-dipyridine
Dimethylbipyridyl
2,2'-Bi(5-methylpyridine) | [Molecular Formula]
C12H12N2 | [MDL Number]
MFCD01740554 | [Molecular Weight]
184.24 | [MOL File]
1762-34-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
114-117 °C(lit.) | [Boiling point ]
140℃/3mm | [density ]
1.060±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMF: 15mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL | [form ]
powder to crystal | [pka]
4.78±0.32(Predicted) | [color ]
White to Yellow to Orange | [InChI]
InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3 | [InChIKey]
PTRATZCAGVBFIQ-UHFFFAOYSA-N | [SMILES]
C1(C2=NC=C(C)C=C2)=NC=C(C)C=C1 | [CAS DataBase Reference]
1762-34-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DW1766000
| [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
mouse,LD50,intraperitoneal,225mg/kg (225mg/kg),Toxicon. Vol. 23, Pg. 815, 1985. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Dichloromethane-->Magnesium sulfate-->Triphenylphosphine-->Diglyme-->Sodium tert-butoxide-->Nickel(II) acetate tetrahydrate-->2-Bromo-5-methylpyridine-->5,6'-Dimethyl-[2,2']bipyridinyl-->6,6'-Dimethyl-2,2'-dipyridyl-->5-Methyl-2-(tributylstannyl)pyridine, 96%-->2-Amino-5-methylpyridine-->2-Bromo-6-methylpyridine-->2-Chloro-5-methylpyridine | [Preparation Products]
BIPY531, 2,2'-([2,2'-Bipyridine]-5,5'-diyl)diacetonitrile-->5,5'-diMethoxycarbonyl-2,2'-bipyridine |
| Hazard Information | Back Directory | [Uses]
5,5'-Dimethyl-2,2'-bipyridine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is also used as a raw material in the synthesis of dyestuffs and agrochemicals. It is used as a precursor for the preparation of 5-methyl-5?vinyl-2,2?-bipyridine. | [Definition]
ChEBI: Abametapir is a member of bipyridines. | [Mechanism of action]
5 5'-Dimethyl-2,2-bipyridine works by inhibiting metalloproteinase enzymes that are essential for lice egg growth and development.
| [Synthesis]
2-Amino-5-methylpyridine ((Abametapir))(100) was converted to 2-bromo-5-methylpyridine (101) via the Sandmeyer reaction using bromine and sodium nitrite in 75% yield. Next, 101 was converted to abametapir (XIV) via a palladium-catalyzed homocoupling reaction in 79% yield. Abametapir was finally isolated by crystallization from a water/isopropanol mixture.
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Henan Jiuke Chemical Co. LTD Gold
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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