| Identification | More | [Name]
DI-2-PYRIDYL KETONE | [CAS]
19437-26-4 | [Synonyms]
2,2'-CARBONYLDIPYRIDINE
2,2'-DIPYRIDYL KETONE
DI-2-PYRIDYL KETONE
2-Pyridyl ketone
Bis(2-pyridyl) ketone
Di(2-pyridinyl)methanone
Di(pyridin-2-yl) ketone
Di-2-Pyridyldiketone
Ketone, di-2-pyridyl
Methanone, di-2-pyridinyl-
Dipyridylketone
DIPYRIDIN-3-YLMETHANONE
2,2μ-Carbonyldipyridine, 2,2μ-Dipyridyl ketone
Di-2-pyridyl ketone ,98%
2,2'-Carbonylbispyridine
Bis(2-pyridinyl) ketone
Di(2-pyridinyl) ketone | [EINECS(EC#)]
243-067-3 | [Molecular Formula]
C11H8N2O | [MDL Number]
MFCD00006288 | [Molecular Weight]
184.19 | [MOL File]
19437-26-4.mol |
| Questions And Answer | Back Directory | [Synthesis]
Under stirring, a solution of n-butyllithium (5.3 mL, 1.2 M) in n-hexane was slowly added dropwise (6.33 mmol) to 2-bromopyridine (6.33 mmol) dissolved in tetrahydrofuran (THF 10 mL). The resulting reaction mixture was stirred at -78 °C for 1 hour, followed by the addition of ethyl chloroformate (0.3 mL, 2.85 mmol). The reaction mixture was then brought to room temperature and stirred for 12 hours. After the reaction was complete, 5 mL of water was added to quench the reaction. The aqueous layer was then extracted with dichloromethane (3 × 10 mL), and the combined organic matter was washed with NaHCO3 (15 mL saturated aqueous solution) and brine (10 mL). The organic layer was then dried over MgSO4, and the solution was filtered. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography to obtain the target product molecule. 
|
| Chemical Properties | Back Directory | [Appearance]
beige to brown crystalline powder | [Melting point ]
52-55 °C (lit.) | [Boiling point ]
115-125 °C(Press: 0.1 Torr) | [density ]
1.196±0.06 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Liquid | [pka]
2.30±0.10(Predicted) | [color ]
Clear colorless to yellow | [Water Solubility ]
Low solubility in water. | [Detection Methods]
HPLC | [BRN ]
126598 | [InChI]
InChI=1S/C11H8N2O/c14-11(9-5-1-3-7-12-9)10-6-2-4-8-13-10/h1-8H | [InChIKey]
QPOWUYJWCJRLEE-UHFFFAOYSA-N | [SMILES]
C(C1=NC=CC=C1)(C1=NC=CC=C1)=O | [CAS DataBase Reference]
19437-26-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10 | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to brown crystalline powder | [Uses]
di-2-Pyridyl ketone has been used in the preparation of unusual {Ni(II)(3)Ln(III)(μ-OR)(6)}(3+) complexes with a "star" topology. Its monoanionic form has been used in the synthesis of triangular Ni(2)M (M = lanthanide, Y) complexes. | [Uses]
di-2-Pyridyl ketone has been used in the preparation of unusual {Ni(II)(3)Ln(III)(?-OR)(6)}(3+) complexes with a "star" topology. Its monoanionic form has been used in the synthesis of triangular Ni(2)M (M = lanthanide, Y) complexes. The Schiff base ligands derived from di-2-pyridyl ketone exhibit ant proliferative activity in SK-N-MC neuroepithelioma (cancer) cells. | [Biochem/physiol Actions]
The Schiff base ligands derived from di-2-pyridyl ketone exhibit antiproliferative activity in SK-N-MC neuroepithelioma (cancer) cells. |
|
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J & K SCIENTIFIC LTD.
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