| Identification | Back Directory | [Name]
Angiotensin II, 5-L-isoleucine-8-glycine- | [CAS]
40678-47-5 | [Synonyms]
TRV120056
Angiotensin II, 5-L-isoleucine-8-glycine- | [Molecular Formula]
C43H65N13O12 | [MDL Number]
MFCD34470691 | [MOL File]
40678-47-5.mol | [Molecular Weight]
956.07 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.67±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Asp-Arg-Val-Tyr-Ile-His-Pro-Gly |
| Hazard Information | Back Directory | [Uses]
TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1]. | [References]
[1] Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77. DOI:10.1124/mol.111.072801
[2] Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24. DOI:10.1074/jbc.M114.548131 |
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