| Identification | More | [Name]
Methyl phenoxyacetate | [CAS]
2065-23-8 | [Synonyms]
METHYL PHENOXYACETATE
PHENOXYACETIC ACID METHYL ESTER
PHENOXY METHYL ACETATE
phenoxy-aceticacimethylester
Acetic acid, phenoxy-, methyl ester
Methyl（ethyl）phenoxyacetate
Phenoxyacetic acid methyl | [EINECS(EC#)]
218-176-4 | [Molecular Formula]
C9H10O3 | [MDL Number]
MFCD00010227 | [Molecular Weight]
166.17 | [MOL File]
2065-23-8.mol |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
T | [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Methyl phenoxyacetate (MPOA) was used as an acylating agent in the synthesis of loracarbef, a carbacephalosporin antibiotic. | [Preparation]
synthesis of methyl phenoxyacetate: methyl bromoacetate (10 mL, 105.6 mmol) and phenol (9.9380 g, 105.6 mmol) were dissolved in 250 mL of acetone; K2CO3 (21.89 g, 158 mmol) and KI (5 g, 30 mmol) were added and the mixture heated to reflux with stirring overnight. The mixture was filtered and the resultant solution concentrated in vacuo. Deionized water (200 mL) was added. The reaction mixture was extracted with 50 mL ethyl acetate three times. The combined ethyl acetate layers were washed with brine, dried over MgSO4, and filtered. All ethyl acetate was removed in vacuo, resulting in a slightly yellow liquid (80% yield). |
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