| Identification | More | [Name]
Ethyl pyrrole-2-carboxylate | [CAS]
2199-43-1 | [Synonyms]
1H-PYRROLE-2-CARBOXYLIC ACID, ETHYL ESTER
ETHYL 1H-PYRROLE-2-CARBOXYLATE
ETHYL PYRROLE-2-CARBOXYLATE
PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER
RARECHEM AL BI 0174
SALOR-INT L305596-1EA
Ethyl Pyrrole-2-Carbonate
ethyl pyrrole-2-carboxylatePyrrole-2-carboxylic acid,ethyl ester
Ethyl pyrrole-2-carboxylate, 98+% | [Molecular Formula]
C7H9NO2 | [MDL Number]
MFCD00817049 | [Molecular Weight]
139.15 | [MOL File]
2199-43-1.mol |
| Questions And Answer | Back Directory | [Synthesis]
The preparation method of ethyl pyrrole-2-carboxylate is as follows: A solution of 2,2,2-trichloro-1-(1H-pyrrole-2-yl)-acetone (25 g, 0.12 mol) in ethanol (200 mL) was treated with potassium carbonate (5 g). The mixture was then heated to reflux for 1 hour. After this, the solid residue was filtered off, and the solution was concentrated under reduced pressure. Ethyl acetate (200 mL) was added, and the solution was washed with water (2×). The organic phase was dried on Na₂SO₄. Ethyl pyrrole-2-carboxylate (18 g) was obtained as a pale yellow solid. HPLC (Method 2): m/z 140.12 [m+H]+, 1H NMR (400.5 MHz, DMSO-d6) δppm 1.29 (t, J=7.0 Hz, 3H), 4.23 (q, J=700 Hz, 2H), 6.25–6.04 (m, 1H), 6.86–6.65 (m, 2H).
Figure: Synthetic Route of Ethyl Pyrrole-2-Carboxylate |
| Chemical Properties | Back Directory | [Melting point ]
37-39°C | [Boiling point ]
70°C 0,8mm | [density ]
1.139±0.06 g/cm3(Predicted) | [Fp ]
70°C/0.8mm | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
15.25±0.50(Predicted) | [color ]
White to Yellow to Orange | [BRN ]
2645 | [InChI]
InChI=1S/C7H9NO2/c1-2-10-7(9)6-4-3-5-8-6/h3-5,8H,2H2,1H3 | [InChIKey]
PAEYAKGINDQUCT-UHFFFAOYSA-N | [SMILES]
N1C=CC=C1C(OCC)=O | [LogP]
1.730 (est) | [CAS DataBase Reference]
2199-43-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Ethyl pyrrole-2-carboxylate is white or light yellow crystalline
| [Uses]
Ethyl pyrrole-2-carboxylate is a pyrole derivative used in the preparation of heterocyclic bioactive agents and other pharmaceutical compounds. A catalyst in olefin polymerization.
| [Definition]
ChEBI: Ethyl 2-pyrrolecarboxylate is a member of pyrroles. | [Synthesis Reference(s)]
Tetrahedron Letters, 27, p. 6315, 1986 DOI: 10.1016/S0040-4039(00)87796-5 |
|
| Company Name: |
Cool Pharm, Ltd Gold
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
|