| Identification | More | [Name]
7-Amino-3-methyl-3-cephem-4-carboxylic acid | [CAS]
22252-43-3 | [Synonyms]
7-Aminodezacetoxycephalosporanic acid
7-amino-3-methyl-3-cephem-4-carboxylic
ADCA
7-Amino deacetoxy cefalosporanic acid
7-Amino-3-desacetoxy cephalosporanic acid
6R,7R)-7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
7-Amino-3-deacetoxycephalosporanic Acid
Deacetoxycephalosporanic Acid
7-AMINODESACETOXY-CEPHALOSPORANIC ACID 98.5%
(6R-trans)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-ADCA
7-Amino-3-methyl-3-cephem-4-carboxylic acid
7-Aminodeacetoxycephalosporanic ccid
7-ACT
(7R)-3-Methyl-7-aminocepham-3-ene-4-carboxylic acid
(7R)-7-Amino-3-methylcepham-3-ene-4-carboxylic acid
3-Methyl-7β-aminocepham-3-ene-4-carboxylic acid | [EINECS(EC#)]
244-870-1 | [Molecular Formula]
C8H10N2O3S | [MDL Number]
MFCD00151456 | [Molecular Weight]
214.24 | [MOL File]
22252-43-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Powder | [Melting point ]
234°C (dec.) | [Boiling point ]
517.6±50.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [vapor pressure ]
0Pa at 20℃ | [refractive index ]
104 ° (C=1, 1mol/L HCl) | [storage temp. ]
2-8°C
| [solubility ]
Do you have solubility information on this product that you would like to share | [form ]
powder | [pka]
3.04±0.50(Predicted) | [color ]
White to Orange to Green | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble in water (partly), 1M ammonium hydroxide (50 mg/ml), and DMSO (Sparingly). | [Usage]
A metabolite of Cephalexin | [BRN ]
5273616 | [InChI]
InChI=1S/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m1/s1 | [InChIKey]
NVIAYEIXYQCDAN-CLZZGJSISA-N | [SMILES]
N12[C@@]([H])([C@H](N)C1=O)SCC(C)=C2C(O)=O | [LogP]
-3.8--2.8 at 20℃ and pH3.6-7 | [CAS DataBase Reference]
22252-43-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R42/43:May cause sensitization by inhalation and skin contact .
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
2941901010 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Powder | [Uses]
A metabolite of Cephalexin (C256800). | [Definition]
ChEBI: A cephem monocarboxylic acid derivative having a structure based on cephalosporanic acid, deacetoxylated and carrying a 7beta-amino group. | [Biological Activity]
7-ADCA is produced from penicillin G made by Penicillium chrysogenum involving several polluting chemical steps followed by enzymatic deacylation using penicillin acylase . | [Synthesis]
The existing preparation method usually employs acylase to cleave 7-phenylacetamidocephalosporanic acid, and then obtains 7-ADCA by acidification, dichloromethane extraction to remove impurities, activated charcoal decolorization and crystallization, etc. |
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