| Identification | More | [Name]
5-Bromo-1-benzofuran | [CAS]
23145-07-5 | [Synonyms]
5-BROMO-1-BENZOFURAN
5-BROMOBENZO[BETA]FURAN
5-BROMOBENZOFURAN
BUTTPARK 95\50-66
5-Bromobenzo[b]furan
5-Bromobenzo[beta]furan, 98 %
5-Bromobenzofuran ,97% | [Molecular Formula]
C8H5BrO | [MDL Number]
MFCD03407317 | [Molecular Weight]
197.03 | [MOL File]
23145-07-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
8°C(lit.) | [Boiling point ]
226°C(lit.) | [density ]
1.573 g/mL at 25 °C | [refractive index ]
n20/D1.605 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
liquid | [color ]
Colourless to light yellow | [Detection Methods]
HPLC,NMR | [InChI]
InChI=1S/C8H5BrO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H | [InChIKey]
AYOVPQORFBWFNO-UHFFFAOYSA-N | [SMILES]
O1C2=CC=C(Br)C=C2C=C1 | [CAS DataBase Reference]
23145-07-5(CAS DataBase Reference) | [EPA Substance Registry System]
23145-07-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29329990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow liquid | [Uses]
5-Bromobenzofuran is used in the synthesis of 1-(7-benzofuranyl)-4-methylpiperazine; a compound shown to bind strongly and with high selectivity to the serotonin receptor 5-HT2A in the presence of the receptor 5-HT7 in vitro. | [Synthesis]
The general procedure for the synthesis of 5-bromobenzofuran from 4-bromophenoxyacetaldehyde diethyl acetal was as follows: polyphosphoric acid (10 g) was added to a solution of benzene (50 mL), the product of step A (8.4 g). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and slowly poured into ice water (80 mL). The aqueous phase was extracted with ether and the organic phases were combined. The ether layer was washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 4.9 g of crude product in 85% yield. | [References]
[1] Patent: WO2004/33440, 2004, A1. Location in patent: Page 239-240
[2] Patent: US2004/147559, 2004, A1. Location in patent: Page 122
[3] Patent: US2004/106794, 2004, A1. Location in patent: Page 123
[4] Patent: WO2005/66147, 2005, A1. Location in patent: Page/Page column 209
[5] Patent: WO2005/68460, 2005, A1. Location in patent: Page/Page column 203 |
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