| Identification | More | [Name]
1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE | [CAS]
25016-09-5 | [Synonyms]
1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE
1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXALDEHYDE
1,3-DIMETHYLPYRAZOLE-5-CARBOXALDEHYDE
2,5-DIMETHYL-2 H-PYRAZOLE-3-CARBALDEHYDE
AKOS B015985
ART-CHEM-BB B015985
1,3-Dimethylpyrazole-5-carbaldehyde
1,3-Dimethyl-1h-pyrazole-5-carbaldehyde, 90+%
1,3-Dimethyl-1H-pyrazole-5-carbaldehyde ,97% | [Molecular Formula]
C6H8N2O | [MDL Number]
MFCD02681907 | [Molecular Weight]
124.14 | [MOL File]
25016-09-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
40-42°C | [Boiling point ]
80-83 °C(Press: 12 Torr) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
1.03±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Detection Methods]
HPLC | [CAS DataBase Reference]
25016-09-5(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29331990 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid | [Synthesis]
Step 2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15)
A mixture of compound 14 (1,3-dimethyl-5-hydroxymethyl-1H-pyrazole, 3 g, 23.8 mmol) with pyridinium dichromate (13.4 g, 35.7 mmol) in dichloromethane (100 ml) was reacted for 16 hrs at 25°C under nitrogen protection with stirring. After completion of the reaction, the reaction mixture was filtered and the filtrate was collected. The filtrate was dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography to afford the target product 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) as a 1 g brown solid in 34% yield.
Product characterization data:
1H NMR (200 MHz, CDCl3): δ 9.8 (s, 1H), 6.6 (s, 1H), 4.1 (s, 3H), 2.3 (s, 3H).
Mass spectrum (CI method, isobutane): 125 (M + 1, 100%).
IR spectrum (KBr, cm-1): νmax 1688. | [References]
[1] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 98
[2] Patent: WO2005/9941, 2005, A1. Location in patent: Page 45-46
[3] Patent: WO2009/101082, 2009, A1. Location in patent: Page/Page column 71 |
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