| Identification | Back Directory | [Name]
Ethyl methyldopate hydrochloride | [CAS]
2508-79-4 | [Synonyms]
METHYLDOPATE HCL
METHYLDOPAETHYLHCL
Ethyl ester hydrochloride
METHYLDOPATE HYDROCHLORIDE
QSRVZCCJDKYRRF-YDALLXLXSA-N
methyldopa ethyl hydrochloride
ethyl methyldopate hydrochloride
Methyldopate Hydrochloride (200 mg)
methyldopa ethyl ester hydrochloride
3-hydroxy-a-methyl- L-Tyrosine ethyl ester, hydrochloride (1:1)
L-Tyrosine, 3-hydroxy-α-methyl-, ethyl ester, hydrochloride (1:1)
Levo-3-(3,4-dihydroxyphenyl)-2-methylalanine ethyl ester hydrochloride
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate hydrochloride
ethyl (2S)-2-azanyl-3-(3,4-dihydroxyphenyl)-2-methyl-propanoate hydrochloride
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propionic acid ethyl ester hydrochloride | [EINECS(EC#)]
219-720-3 | [Molecular Formula]
C12H17NO4.ClH | [MDL Number]
MFCD07787407 | [MOL File]
2508-79-4.mol | [Molecular Weight]
275.73 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [form ]
crystalline powder | [Major Application]
pharmaceutical
pharmaceutical small molecule | [InChI]
1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1 | [InChIKey]
QSRVZCCJDKYRRF-YDALLXLXSA-N | [SMILES]
[Cl-].N[C@](Cc1cc(c(cc1)O)O)(C)C(=O)OCC.[H+] |
| Hazard Information | Back Directory | [Uses]
Ethyl methyldopate hydrochloride is Antihypertensive.
| [Brand name]
Aldomet (Merck). | [General Description]
Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter. | [Clinical Use]
Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.
| [in vivo]
Methyldopate is hydrolysed in vivo to methyldopa[2]. | [IC 50]
α adrenergic receptor |
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