| Identification | More | [Name]
Molsidomine | [CAS]
25717-80-0 | [Synonyms]
CORVATON
ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate
MOLSIDOMINE
MORSIDOMINE
MORSYDOMINE
MOTAZOMIN
n-carboxy-3-morpholinosynonimine ethyl ester
N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE
N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE
SIN-10
corvasal
molsidolat
morial
n-(ethoxycarbonyl)-3-(4-morpholinyl)-sydnoneimin
n-carboxy-3-morpholino-sydnoneiminethylester
n-carboxy-3-morpholinosydnonimineethylester
n-ethoxycarbonyl-3-morpholinosydnonimine
N-Carboxy-3-morpholino-syndone imine ethyl ester
N-Ethoxycarbonyl-3-morphalinosydnomine
N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10 | [EINECS(EC#)]
247-207-4 | [Molecular Formula]
C7H8N2O4 | [MDL Number]
MFCD00869301 | [Molecular Weight]
184.15 | [MOL File]
25717-80-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
140-141°C | [Boiling point ]
385.05°C (rough estimate) | [density ]
1.3186 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride. | [form ]
neat | [pka]
pK (100°) 3.0 ± 0.1 | [color ]
White to Off-White | [λmax]
317nm(MeOH)(lit.) | [Merck ]
14,6234 | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8- | [InChIKey]
XLFWDASMENKTKL-NTMALXAHSA-N | [SMILES]
[N+]1([N-]O/C(=N\C(=O)OCC)/C=1)N1CCOCC1 | [CAS DataBase Reference]
25717-80-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
WU7677400
| [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi) |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Originator]
Corvasal,Hoechst | [Uses]
Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitr
ic oxide donor. | [Definition]
ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines. | [Manufacturing Process]
1.6 parts by volume of ethyl chloroformate is stirred dropwise into a
suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in
5 parts by volume of pyridine, and the mixture is agitated for a while to allow
reaction to take place. Pyridine is removed from the reaction mixture by
evaporation, and the residue is dissolved in a small amount of water and
extracted with chloroform several times. The extract is dehydrated by adding
anhydrous magnesium sulfate and subjected to filtration. Chloroform is
removed from the filtrate by distillation, crude crystals being obtained.
Recrystallization of the crude crystals from toluene gives 0.6 part by weight of
3-morpholino-N-carboethoxysydnonimine having a melting point of 140°-
141°C. Yield 51%. | [Brand name]
Corvaton (Hoechst-Roussel). | [Therapeutic Function]
Coronary vasodilator | [storage]
Store at -20°C,protect from light |
|
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