| Identification | More | [Name]
2-Methyl-4-isothiazolin-3-one hydrochloride | [CAS]
26172-54-3 | [Synonyms]
2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDROCHLORIDE
MIT HYDROCHLORIDE
2-methyl-3(2h)-isothiazolonhydrochloride
3(2H)-Isothiazolone,2-methyl-,hydrochloride
2-methyl-2H-isothiazol-3-one hydrochloride
2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL
N-MethylisothiazoloneHCl
ISO-THIAZOLINONE(KATHON)
2-METHYLISOTHIAZOLONE (MIT) HCL, 99+% | [EINECS(EC#)]
247-499-3 | [Molecular Formula]
C4H6ClNOS | [MDL Number]
MFCD06804636 | [Molecular Weight]
151.61 | [MOL File]
26172-54-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
165-170° | [density ]
1.551 at 21℃ | [vapor pressure ]
0.777-1Pa at 20-25℃ | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [BRN ]
3993054 | [Stability:]
Hygroscopic | [Major Application]
microbiology | [InChI]
InChI=1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H | [InChIKey]
SJXPQSRCFCPWQQ-UHFFFAOYSA-N | [SMILES]
O=C1C=CSN1C.Cl | [LogP]
-0.44 at 20℃ and pH2 | [Surface tension]
71.3mN/m at 1g/L and 20℃ | [CAS DataBase Reference]
26172-54-3(CAS DataBase Reference) | [EPA Substance Registry System]
26172-54-3(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS05,GHS06,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H301-H314-H317-H410 | [Precautionary statements ]
P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1759 8/PG 2
| [WGK Germany ]
3
| [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HazardClass ]
8, 6.1 | [HS Code ]
2934100090 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Corr. 1A
Skin Sens. 1 |
| Hazard Information | Back Directory | [Application]
Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites | [Uses]
Methylisothiazolinone (MIT) has been used:
- as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
- to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites
| [Uses]
Pesticidal substituted 3-isothiazolinones | [General Description]
2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone. | [Biochem/physiol Actions]
2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth. | [storage]
store at 2°C - 8°C,close container well.
|
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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