| Identification | Back Directory | [Name]
Etofenamate | [CAS]
30544-47-9 | [Synonyms]
TV-485
ReuMon
TVX-485
Rheumon
Bayrogel
TrauMon Gel
Etofenamate
Ethofenamate
EtofenaMate,TV-485
EtofenamateEtofenamate
2-(2-Hydroxyethoxy)ethyl FufenaMate
2-(2-hydroxyaethoxy)aethylester der flutenaminsaeure
2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoroMethyl)phenyl)aMino)benzoate
n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid 2-(2-hydroxyethoxy)
2-(2-hydroxyethoxy)ethyl-n-(alpha,alpha,alpha-trifluoro-m-tolyl)anthrani late
Benzoic acid, 2[[3-(trifluoromethyl)phenyl]amino]-2-(hydroxyethoxy)ethyl ester
2-[[3-(TrifluoroMethyl)phenyl]aMino]benzoic Acid 2-(2-Hydroxyethoxy)ethyl Ester | [EINECS(EC#)]
250-231-8 | [Molecular Formula]
C18H18F3NO4 | [MDL Number]
MFCD00242806 | [MOL File]
30544-47-9.mol | [Molecular Weight]
369.33 |
| Chemical Properties | Back Directory | [Melting point ]
25°C | [Boiling point ]
bp.001 130-135° | [density ]
1.2866 (estimate) | [refractive index ]
nD25 1.564 | [storage temp. ]
Refrigerator | [solubility ]
Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate. | [form ]
neat | [pka]
14.32±0.10(Predicted) | [color ]
Light yellow to yellow | [Stability:]
Light Sensitive | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 | [InChIKey]
XILVEPYQJIOVNB-UHFFFAOYSA-N | [SMILES]
C(OCCOCCO)(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Oil | [Usage]
anti-inflammatory;cyclooxygenase inhibitor | [Usage]
histamine H1-receptor antagonist | [Usage]
Medication used to alleviate joint and muscle pain. | [Originator]
Rheumon,Troponwerke,W. Germany,1977 | [Uses]
anti-inflammatory;cyclooxygenase inhibitor | [Uses]
As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.
| [Uses]
Medication used to alleviate joint and muscle pain. | [Definition]
ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester. | [Manufacturing Process]
16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)-
anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to
110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added.
The reaction mixture is then heated to boiling for 2 hours. The precipitated
potassium chloride is filtered off and the solvent is removed by evaporation.
The residue is separated over a column with 400 g of silica gel (particle size
0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid
as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3-
trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale
yellow oil which does not crystallize and cannot be distilled. | [Therapeutic Function]
Antiinflammatory |
| Safety Data | Back Directory | [RIDADR ]
UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1 | [Toxicity]
LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi) |
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