| Identification | More | [Name]
3-Chloro-5-fluorophenylboronic acid | [CAS]
328956-61-2 | [Synonyms]
3-CHLORO-5-FLUOROBENZENEBORONIC ACID
3-CHLORO-5-FLUOROPHENYLBORONIC ACID
AKOS BRN-0721
3-Chloro-5-fluorobenzeneboronic acid 97%
3-Chloro-5-fluorobenzeneboronicacid97%
3-Chloro-5-fluorophenlyboronic acid
3-Chloro-5-fluorobenzeneboronic acid ,98% | [Molecular Formula]
C6H5BClFO2 | [MDL Number]
MFCD06801741 | [Molecular Weight]
174.37 | [MOL File]
328956-61-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
>200°C | [Boiling point ]
308.1±52.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
6.52±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
Slightly soluble in water. | [Detection Methods]
HPLC | [CAS DataBase Reference]
328956-61-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
3-Chloro-5-fluorobenzeneboronic acid is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. | [Uses]
suzuki reaction | [Synthesis]
Grignard's reagent was prepared by dissolving 11.3 g of dried magnesium shavings and 75.0 g of 1-bromo-3-chloro-5-fluorobenzene (S1-1) in 220 ml of anhydrous tetrahydrofuran (THF) under nitrogen protection. The reaction system was cooled to -70 °C and 52.0 g of trimethyl borate dissolved in 200 ml of THF was slowly added dropwise. The reaction temperature of -70°C was maintained and stirred for 3 hours. Subsequently, the reaction system was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, 2N hydrochloric acid was slowly added dropwise to the reaction solution and stirred for 1 hour. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was washed with heptane to give 34.7 g of 3-chloro-5-fluorophenylboronic acid (S1-2) in 55.7% yield. | [References]
[1] Patent: EP2433923, 2012, A1. Location in patent: Page/Page column 68 |
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