| Identification | More | [Name]
Ethyl 2-methoxy-5-sulfamoylbenzoate | [CAS]
33045-53-3 | [Synonyms]
Ethyl 2-methoxy-5-(sulfamoylmethyl)benzoate
2-METHOXYL-5-METHYLSULFONYLBENZOIC ACID METHYL ESTER
Ethyl 2-methoxy-5-sulfamoylbenzoate
Ethyl 5-sulphamoyl-o-anisate | [EINECS(EC#)]
251-359-7 | [Molecular Formula]
C10H13NO5S | [MDL Number]
MFCD01317556 | [Molecular Weight]
259.28 | [MOL File]
33045-53-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
148-151 °C | [Boiling point ]
446.5±55.0 °C(Predicted) | [density ]
1.317±0.06 g/cm3(Predicted) | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
9.95±0.60(Predicted) | [color ]
White to Off-White | [Water Solubility ]
1.545g/L at 25℃ | [LogP]
1.33 | [CAS DataBase Reference]
33045-53-3(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
2-Methoxy-5-sulfonamide ethyl benzoate is an important intermediate for the antipsychotic drugs sulpiride and levosulpiride. Sulpiride, chemically named N-[(1-ethyl-2-pyrrolyl)methyl]-2-methoxy-5-(aminosulfonyl)benzamide, was synthesized by the French in 1967. Due to its therapeutic effects on mental disorders and few adverse reactions, it has been used clinically both domestically and internationally for many years. |
| Hazard Information | Back Directory | [Flammability and Explosibility]
Notclassified | [Synthesis]
In a 1000ml reaction flask equipped with reflux device will be added 300g tetrahydrofuran, 0.25mol2-methoxy-5-chlorobenzoic acid ethyl ester, 1.8g of copper bromide (0.0125mol), 25.7g (0.25mol) of sodium sulfamate, heating to 65 ° C, and maintained at thi |
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