| Identification | More | [Name]
Methyl 2-methoxy-5-sulfamoylbenzoate | [CAS]
33045-52-2 | [Synonyms]
2-METHOXY-5-AMINO SULFONYL BENZOIC ACID METHYL ESTER
2-METHOXY-5-AMINOSULFONYL-METHYL BENZOATE
2-METHOXY-5-SULFAMOYLBENZOIC ACID METHYL ESTER
METHYL 2-METHOXY-5-AMINOSULFONYLBENZOATE
METHYL 2-METHOXY-5-SULFAMOYLBENZOATE
METHYL[5-AMINO SULFONYL-2-METHOXY] BENZOATE
methyl 5-sulphamoyl-o-anisate
2-methoxy-5-sulfamoyl methyl benzoate
5-Aminosulfonyl-2-Methoxy-Benzoic Acid Methyl Ester
2-Methoxy-5-Aminosulfonyl Benzoic Acid Methyl Ester Methyl 2-Methoxy-5-Aminosulfonyl Benzoate
Methyl 5-(aminosulphonyl)-2-methoxybenzoate
METHYL 2-METHOXY-5-SULFAMOYLBENZOATE, 98 %
2-Methoxy-5-sulfamoylbenzoic
2-METHOXY-5-SULFAMIDE METHYL BENZOATE | [EINECS(EC#)]
251-358-1 | [Molecular Formula]
C9H11NO5S | [MDL Number]
MFCD01317542 | [Molecular Weight]
245.25 | [MOL File]
33045-52-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
175-177 °C (lit.) | [Boiling point ]
439.8±55.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
9.94±0.60(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C9H11NO5S/c1-14-8-4-3-6(16(10,12)13)5-7(8)9(11)15-2/h3-5H,1-2H3,(H2,10,12,13) | [InChIKey]
MKDYDRQLKPGNNU-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC(S(N)(=O)=O)=CC=C1OC | [LogP]
0.36 | [CAS DataBase Reference]
33045-52-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
2922500090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
Methyl 2-methoxy-5-sulfamoylbenzoate is a reactant used in the preparation of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypog lycemic agents.
| [Preparation]
Methyl 2-methoxy-5-aminosulfonyl benzoate is an important intermediate for the synthesis of sulpiride, which is the main drug for treatment of psychiatric disorders such as schizophrenia and depression. The synthetic route of methyl 2-methoxy-5-aminosulfonyl benzoate is composed mainly of etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification, which prepared successfully with the help of salicylic acid and methyl salicylate as precursor. The raw materials of the synthetic route are salicylic acid and methyl salicylate, which was synthesized by etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification.
synthetic procedure of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate | [General Description]
Methyl 2-methoxy-5-sulfamoylbenzoate is also referred to as 2-methoxy-5-sulfamoyl methyl benzoate or methyl 5-(aminosulphonyl)-2-methoxybenzoate. |
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