| Identification | More | [Name]
Disodium uridine-5'-monophosphate | [CAS]
3387-36-8 | [Synonyms]
5'-UMP-NA2
5'-URIDYLIC ACID
5'-URIDYLIC ACID DISODIUM SALT
U 5'-P DISODIUM SALT
UMP
UMP 2NA
UMP DISODIUM
UMP DISODIUM SALT
UMP, NA2
URIDINE-5'-MONOPHOSPHATE DISODIUM
URIDINE-5'-MONOPHOSPHATE DISODIUM SALT
URIDINE-5'-MONOPHOSPHORIC ACID, DISODIUM
URIDINE 5'-MONOPHOSPHORIC ACID DISODIUM SALT
5’-umpdisodium
disodium5’-ump
disodium5’-uridylate
disodiumump
disodiumuridine5’-phosphate
uridine,5’-dihydrogenphosphate,disodiumsalt
5`-UMP,2Na | [EINECS(EC#)]
222-211-9 | [Molecular Formula]
C9H11N2Na2O9P | [MDL Number]
MFCD00006525 | [Molecular Weight]
368.14 | [MOL File]
3387-36-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [Melting point ]
208-210 °C
| [refractive index ]
-14 ° (C=1, H2O) | [storage temp. ]
−20°C
| [solubility ]
Water (Slightly) | [form ]
Crystalline Powder | [pka]
6.4, 9.5(at 25℃) | [color ]
White | [biological source]
(chemical) | [Water Solubility ]
40 g/100 mL (20 ºC) | [BRN ]
3582885 | [Stability:]
Very Hygroscopic | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChI]
InChI=1/C9H13N2O9P.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3 | [InChIKey]
KURVIXMFFSNONZ-WFIJOQBCSA-L | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,11,r| | [CAS DataBase Reference]
3387-36-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline | [Uses]
A nucleotide that is a major component of ribonucleic acid. It is found in dietary supplements as well as natural RNA rich foods and has been shown to increase cognitive function in animals. | [Application]
Uridine 5′-monophosphate disodium salt can be used as a cross-linking agent to prepare thermosensitive chitosan hydrogels containing graphene oxide as nanofillers. The hydrogels are attractive materials for use as scaffolds for the regeneration of damaged tissues[3]. | [benefits]
Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In rat PC12 cells, exogenous uridine was shown to elevate intracellular CDP-choline levels by promoting the synthesis of uridine triphosphate (UTP), which was partly converted to CTP. In such cells, uridine also enhances the neurite outgrowth produced by the nerve growth factor (NGF). A study assessed the effect of dietary supplementation with uridine-5'-monophosphate disodium (UMP-2Na+, an additive in infant milk formulas) on striatal dopamine (DA) release in aged rats. Potassium (K+)-evoked DA release was significantly greater among UMP-treated rats, i.e., 341+/-21% of basal levels vs. 283+/-9% of basal levels in control rats (p<0.05); basal DA release was unchanged. The levels of neurofilament-70 and neurofilament-M proteins, biomarkers of neurite outgrowth, increased to 182+/-25% (p<0.05) and 221+/-34% (p<0.01) of control values, respectively, with UMP consumption. Hence, UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo[2]. | [General Description]
Uridine 5′-monophosphate is a pyrimidine mononucleotide. It is formed by decarboxylation of orotidine 5′-monophosphate. UMP is further converted to UTP (uridine 5′-triphosphate) using kinases. | [References]
[1] Soleimani, Farahnaz, and F. Gharib. "Protonation Constants of Uridine 5′-Monophosphate in Different Aqueous Solutions of Methanol." Journal of Solution Chemistry 43.4(2014):763-773.
[2] Lei Wang. “Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.” Journal of Molecular Neuroscience 27 1 (2005): 137–145.
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