| Identification | More | [Name]
D-Methionine | [CAS]
348-67-4 | [Synonyms]
D-2-AMINO-4-[METHYLTHIO]BUTANOIC ACID
d-2-amino-4-(methylthio)butyric acid
D-BANTHIONINE
D-LOBAMINE
D-METHIONINE
H-D-MET-OH
(R)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID
(r)-methionine
d-methionin
D-Metionien
Methionine d-form
Methionine, D-
R-Methionine
D-METHIONINE, 99+% (98% EE/GLC)
D-Methionine,99%
(r)-2-amino-4-(methylthio)butyric acid
D-Methionine (9CI)
Methionine, D-(8CI)
NSC 45689
d-metionien (australian) | [EINECS(EC#)]
206-483-6 | [Molecular Formula]
C5H11NO2S | [MDL Number]
MFCD00002622 | [Molecular Weight]
149.21 | [MOL File]
348-67-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
273-275 °C
| [alpha ]
-24 º (c=8, 6N HCl) | [Boiling point ]
306.9±37.0 °C(Predicted) | [density ]
1.113 (estimate) | [refractive index ]
1.5216 (estimate) | [storage temp. ]
0-6°C | [solubility ]
53 g/L (20°C) | [form ]
Powder | [pka]
2.23±0.10(Predicted) | [color ]
White to off-white | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
53 g/L (20 ºC) | [Merck ]
14,5975 | [BRN ]
1722293 | [Major Application]
cell analysis
peptide synthesis | [InChI]
1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1 | [InChIKey]
FFEARJCKVFRZRR-SCSAIBSYSA-N | [SMILES]
CSCC[C@@H](N)C(O)=O | [LogP]
0.370 (est) | [CAS DataBase Reference]
348-67-4(CAS DataBase Reference) | [NIST Chemistry Reference]
D-(l)-Methionine(348-67-4) | [EPA Substance Registry System]
348-67-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R33:Danger of cumulative effects.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
PD0455000
| [TSCA ]
Yes | [HS Code ]
29304000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
D-Methionine is used to rescue noise-induced hearing loss. It is used to improve the nutritive value of animal feed. | [Definition]
ChEBI: An optically active form of methionine having D-configuration. | [Biochem/physiol Actions]
D-methionine has been shown to rescue noise-induced hearing loss. | [Synthesis]
The general procedure for the determination of N-d-AAase activity using N-acetyl-D-methionine as substrate was as follows: first, N-d-AAase was incubated with N-acetyl-D-methionine at 4°C. Subsequently, a colorimetric solution mixture containing d-amino acid oxidase (coupled with horseradish peroxidase), peroxidase (10 U/mL), 4-aminoantipyrine (0.04 mg/mL) and phenol (0.8 mM) was added. Absorbance (OD) was measured at 520 nm. The unit of enzyme activity was defined as the amount of catalytic production of 1 μmol D-methionine per minute. Protein concentration was determined by the Bradford method using bovine serum albumin as standard [32]. The kinetic parameters kcat and Km were determined by fitting the initial rate as a function of substrate concentration to the Michaelis-Menten equation. | [References]
[1] Journal of the American Chemical Society, 1953, vol. 75, p. 4058
[2] Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 4604
[4] Bulletin of the Agricultural Chemical Society of Japan, 1957, vol. 21, p. 235,237
[5] Bioscience, biotechnology, and biochemistry, 1992, vol. 56, # 9, p. 1392 - 1395 |
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