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359-13-7

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359-13-7 Structure

359-13-7 Structure
IdentificationMore
[Name]

2,2-Difluoroethanol
[CAS]

359-13-7
[Synonyms]

2,2-DIFLUOROETHANOL
AKOS B019710
ART-CHEM-BB B019710
CHF2CH2OH
Ethanol, 2,2-difluoro-
2,2-Difluoroethanol,95%
2,2-Difluoroethanol 97%
2,2-Difluoroethanol97%
2,3-Difluoroethanol
[EINECS(EC#)]

670-547-3
[Molecular Formula]

C2H4F2O
[MDL Number]

MFCD00042248
[Molecular Weight]

82.05
[MOL File]

359-13-7.mol
Chemical PropertiesBack Directory
[Melting point ]

-28°C
[Boiling point ]

95 °C
[density ]

1.296
[refractive index ]

1.338
[Fp ]

3°C
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

soluble in chloroform, ethanol.
[form ]

clear liquid
[pka]

13.00±0.10(Predicted)
[color ]

Colorless to Almost colorless
[Specific Gravity]

1.296
[BRN ]

1731617
[CAS DataBase Reference]

359-13-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Difluoroethanol(359-13-7)
[EPA Substance Registry System]

2,2-Difluoroethanol (359-13-7)
Safety DataBack Directory
[Symbol(GHS) ]

Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H315-H319-H335
[Precautionary statements ]

P261-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
[Hazard Codes ]

F,T
[Risk Statements ]

R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S16:Keep away from sources of ignition-No smoking .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

1987
[Hazard Note ]

Flammable
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29055900
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

2,2-Difluoroethanol(359-13-7).msds
Hazard InformationBack Directory
[Chemical Properties]

Colorless Liquid
[Uses]

2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.
[Synthesis Reference(s)]

Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005
[Synthesis]

2,2-Difluoroethyl Acetate

1550-44-3

2,2-Difluoroethanol

359-13-7

Example 13: Synthesis of 2,2-difluoroethanol from ethyl 2,2-difluoroacetate (Step b2) In a 0.5 L glass reactor equipped with a mechanical stirrer, reflux condenser and temperature probe, 164 g of ethyl 2,2-difluoroacetate (GC purity 95%), 106 g of methanol, and 3 g of solid NaOH were added. the reaction was carried out at 65 °C for 2 h until the conversion was complete. The 2,2-difluoroethanol was isolated by distillation to give 96.3% GC purity and 87% isolated yield.

[References]

[1] Patent: CN107986944, 2018, A. Location in patent: Paragraph 0020; 0023; 0026; 0029; 0032
[2] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 12
[3] Patent: US2014/243561, 2014, A1. Location in patent: Paragraph 0040; 0041; 0042
[4] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 10
[5] Patent: CN108178723, 2018, A. Location in patent: Paragraph 0015; 0016; 0018; 0020
Spectrum DetailBack Directory
[Spectrum Detail]

2,2-Difluoroethanol(359-13-7)MS
2,2-Difluoroethanol(359-13-7)1HNMR
2,2-Difluoroethanol(359-13-7)13CNMR
2,2-Difluoroethanol(359-13-7)IR1
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

2,2-Difluoroethanol, 97%(359-13-7)
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