| Identification | More | [Name]
2-Bromo-4'-fluoroacetophenone | [CAS]
403-29-2 | [Synonyms]
2-BROMO-1-(4-FLUOROPHENYL)ETHANONE
2'-BROMO-4-FLUOROACETOPHENONE
2-BROMO-4'-FLUOROACETOPHENONE
4-FLUOROPHENACYL BROMIDE
AKOS BBS-00003857
ALPHA-BROMO-4-FLUOROACETOPHENONE
BUTTPARK 41\03-58
P-FLUOROPHENACYL BROMIDE
TIMTEC-BB SBB006561
Bromo-4-fluoroacetophenone
Ethanone, 2-bromo-1-(4-fluorophenyl)-
omega-Bromo-4-fluoroacetophenone
2-bromo-1-(4-fluorophenyl)ethan-1-one
alpha-Bromo-4-Fluoro Acetophenone 2'-Bromo-4-Fluoro Acetophenone
z-Bromo-4-fluoroacetophenone
4-Fluorophenacyl bromide (alpha-Bromo-4-fluoroacetophenone), 97%
Ethanone, 2-bromo-1-(4-fluorophenyl)-(9CI)
4-Fluorophenacylbromide,97%
4-Fluorophenacyl bromide 97%
4-fluorophenacyl bromide ,2-bromo-1-(4-fluorophenyl)ethanone | [EINECS(EC#)]
206-955-1 | [Molecular Formula]
C8H6BrFO | [MDL Number]
MFCD00040830 | [Molecular Weight]
217.04 | [MOL File]
403-29-2.mol |
| Chemical Properties | Back Directory | [Appearance]
beige to light grey-green cryst. powder or flakes | [Melting point ]
47-49 °C(lit.) | [Boiling point ]
150 °C12 mm Hg(lit.) | [density ]
1.5728 (rough estimate) | [refractive index ]
1.5450 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Keep Cold | [solubility ]
Soluble in methanol. | [form ]
Powder | [color ]
White to brownish-yellow to light grey | [Sensitive ]
Lachrymatory | [Detection Methods]
HPLC | [BRN ]
637863 | [CAS DataBase Reference]
403-29-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetophenone, 2-bromo-4'-fluoro-(403-29-2) | [Storage Precautions]
Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive/Lachrymatory/Keep Cold | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to light grey-green cryst. powder or flakes | [Uses]
2-Bromo-4’fluoroacetophenone is a intermediate in the synthetic preparation of competitive inhibitors of aromatase. | [Uses]
2-Bromo-4'-fluoroacetophenone is used as an organic chemical synthesis intermediate. | [Synthesis]
General procedure for the synthesis of 2-bromo-4'-fluoroacetophenone using 4-fluoroacetophenone as starting material: general method: oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 ml) solution of 4-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol), and the reaction mixture was stirred at room temperature (or refluxed at temperature reaction). The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate, followed by extraction with ethyl acetate (3 x 25 ml). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-4'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data. | [References]
[1] Farmaco, 1993, vol. 48, # 6, p. 857 - 869
[2] Synthesis, 2008, # 2, p. 253 - 266
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[5] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334 |
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