| Identification | Back Directory | [Name]
246TRIHYDROXYCHALCONE | [CAS]
4197-97-1 | [Synonyms]
246TRIHYDROXYCHALCONE
2-Propen-1-one, 3-phenyl-1-(2,4,6-trihydroxyphenyl)- | [Molecular Formula]
C15H12O4 | [MDL Number]
MFCD00597209 | [MOL File]
4197-97-1.mol | [Molecular Weight]
256.25 |
| Chemical Properties | Back Directory | [Melting point ]
189.9℃ | [Boiling point ]
487.9±45.0 °C(Predicted) | [density ]
1.384±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
6.86±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2]. | [Definition]
ChEBI: Pinocembrin chalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively. It has a role as a plant metabolite and an antifungal agent. It is functionally related to a trans-chalcone. | [in vivo]
Pinocembrin chalcone (30 mg/kg, oral gavage, daily for 3 weeks) improves glucose tolerance and fat accumulation through fatty acid oxidation rate increase in skeletal muscle, which is mainly mediated by AMPK activation in HFD-induced diabetic mice[2].
| Animal Model: | HFD-induced diabetic mice[2] | | Dosage: | 30 mg/kg | | Administration: | oral gavage, daily for 3 weeks | | Result: | Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice. |
| [References]
[1] P D Bremner, et al. Pinocembrin Chalcone: An Antibacterial Compound From Helichrysum Trilineatum. Planta Med. 1998 Dec;64(8):777. DOI:10.1055/s-2006-957585
[2] Shin J, et al. Antidiabetic effects of trihydroxychalcone derivatives via activation of AMP-activated protein kinase[J]. Journal of Industrial and Engineering Chemistry, 2018, 60: 177-184. |
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BioBioPha Co., Ltd.
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