| Identification | More | [Name]
3-Hydroxy-N-methyl-3-phenyl-propylamine | [CAS]
42142-52-9 | [Synonyms]
3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE
3-METHYLAMINO-1-PHENYL-1-PROPANOL
3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL
3-METHYLAMINO-1-PHENYLPROPANOL
ALPHA-(2-METHYLAMINO)-ETHYLBENZENEMETHANOL
ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL
N-METHYL-3-HYDROXY-3-PHENYL PROPYLAMINE
N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE
A-[2-(Methylamino)Ethyl]Benzenemethanol
3-N-methyl-1-phenyl-propanol
α-[2-(Methylamino)ethyl]benzenemethanol
N-Methyl-3-Phenyl-3-Hydroxypropylamin
3-Methylamino-1-phenylpropane-1-ol
3-Hydroxy-N-methyl-3-phenyl-pr
α-[2-(methylamino)ethyl]benzyl alcohol
1-PHENYL-3-METHYLAMINO-1-PROPANOL
PHENYL METHYL AMINO PROPANOL
BENZENEMETHANOL,A-[2-(METHYLAMINO)ETHYL]
3-methylamino-1-phenylpropano
Benzenemethanol, α-[2-(methylamino)ethyl]- | [EINECS(EC#)]
255-679-8 | [Molecular Formula]
C10H15NO | [MDL Number]
MFCD00674078 | [Molecular Weight]
165.23 | [MOL File]
42142-52-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
64 °C | [Boiling point ]
170 °C / 31mmHg | [density ]
1.017±0.06 g/cm3(Predicted) | [vapor pressure ]
0.037Pa at 25℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Soluble), Methanol (Slightly) | [form ]
Solid | [pka]
14.24±0.20(Predicted) | [color ]
Off-White to Pale Yellow | [InChI]
InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3 | [InChIKey]
XXSDCGNHLFVSET-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1)(O)CCNC | [LogP]
0.98 | [CAS DataBase Reference]
42142-52-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P264-P270-P301+P312-P501 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3 | [REACH Registrations]
Active | [HS Code ]
2922199695 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.
| [Synthesis]
3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.
| [References]
[1] Patent: CN103992236, 2016, B. Location in patent: Paragraph 0051;0054; 0055
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1687 - 1689 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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